A degradable zinc-based microporous drug-loaded stent and its preparation method

Abstract

The invention relates to a degradable zinc-based microporous drug-loaded stent and a preparation method thereof. The stent includes a degradable zinc-based material stent matrix, the surface of the stent matrix is ​​provided with uniform drug-loaded micropores, and the surface of the stent is provided with uniform drug-loaded micropores Covered with a therapeutic drug coating, the stent matrix is ​​a cylindrical network structure; the preparation method includes: 1) processing the degradable zinc-based material into the stent matrix; 2) performing surface pretreatment on the stent matrix; 3) the stent 4) corroding the polished stent substrate; 5) pickling the corroded stent substrate; 6) coating the surface of the stent substrate with therapeutic drugs after pore making. The stent prepared by the present invention maintains the good support of the stent after being implanted for more than 4 months due to the superior corrosion resistance of the zinc alloy matrix material, and the matrix surface has uniform micropores and is coated with a therapeutic drug layer, which can control drug release. Give full play to the supporting effect of metal stents, and the medical efficacy of drug-eluting stents to inhibit restenosis caused by excessive intimal hyperplasia.

Description

technical field [0001] The invention relates to a biodegradable metal drug-eluting stent and a preparation method thereof, belonging to the technical field of implantable medical devices. Background technique [0002] In 1977, Gruentzing successfully performed the first case of percutaneous transluminal coronary angioplasty, which opened the era of simple balloon dilatation for cardiovascular treatment. This new technology without thoracotomy ended the dominance of coronary blood supply in cardiac surgery History of reconstruction. In 1987, Sigwart successfully implemented coronary artery stent surgery for the first time. A large number of clinical experiments confirmed that coronary artery stent implantation can effectively avoid the medical disadvantages of simple balloon expansion, and it was widely accepted as the second milestone in the history of interventional treatment of coronary heart disease. . After the coronary artery stent is implanted, it can maintain a supp...

AI Technical Summary

Problems solved by technology

However, the traditional drug-eluting stent is coated with a layer of drug-containing polymer film on the surface of the stent, and the drug-containing polymer film has a relatively weak blocking effect on the penetration of water molecules. Zinc and zinc alloys and polymer materials will simultaneously At the beginning of degradation, the hydrogen gas produced by the metal degradation will form and cause the polymer membrane to bubble, or even fall off, and the fallen fragments may enter the blood stream, leading to the risk of acute and subacute thrombosis and distal limb thrombosis in patients

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