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Degradable zinc-based micropore drug-loaded support and preparation method thereof

A microporous, drug-loaded technology, applied in medical science, surgery, etc., can solve the problems of polymer membrane bubbling, fragments entering the blood stream, and weak blocking effect, so as to increase local inflammation, good biocompatibility, Inhibition of restenotic effect

Active Publication Date: 2015-09-09
LEPU MEDICAL TECH (BEIJING) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional drug-eluting stent is coated with a layer of drug-containing polymer film on the surface of the stent, and the drug-containing polymer film has a relatively weak blocking effect on the penetration of water molecules. Zinc and zinc alloys and polymer materials will simultaneously At the beginning of degradation, the hydrogen gas produced by the metal degradation will form and cause the polymer membrane to bubble, or even fall off, and the fallen fragments may enter the blood stream, leading to the risk of acute and subacute thrombosis and distal limb thrombosis in patients

Method used

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  • Degradable zinc-based micropore drug-loaded support and preparation method thereof
  • Degradable zinc-based micropore drug-loaded support and preparation method thereof
  • Degradable zinc-based micropore drug-loaded support and preparation method thereof

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preparation example Construction

[0038]The present invention unexpectedly finds that when the degradable zinc-based material is selected as Zn-1%Mg alloy or Zn-1%Mg-0.5%Ca alloy, the drug-loaded micropore size is between 400-500nm, and the micropore depth is 180-500nm. 240nm, when the therapeutic drug is rapamycin and the thickness of the drug coating is 1-20 μm (especially 10-20 μm), the stent of the present invention is particularly excellent in terms of degradation speed, biocompatibility and drug sustained release. performance. The flow chart of the preparation method of a degradable zinc-based microporous drug-loaded stent according to the embodiment of the present invention is as follows: figure 1 shown, including the following steps:

[0039] 1) Process the degradable zinc-based material into a stent matrix; the degradable zinc-based material is composed of pure zinc or zinc alloy material; it can be processed into a vascular stent, a tracheal stent, an esophageal stent, an intestinal stent, a biliary...

Embodiment 1

[0054] A degradable zinc-based microporous drug-loaded stent, comprising a degradable zinc-based material stent matrix, the surface of the stent matrix is ​​provided with uniform drug-loading micropores, and the surface of the stent with uniform drug-loaded micropores is covered with therapeutic drugs-Rapa Mycin coating, the stent matrix is ​​a cylindrical network structure; the degradable zinc-based material is Zn-1%Mg alloy; the drug-loaded micropore size is 400-500nm, and the micropore depth is 180-240nm; coated with drug The thickness of the coating was 10 μm.

Embodiment 2

[0056] A degradable zinc-based microporous drug-loaded stent, comprising a degradable zinc-based material stent matrix, the surface of the stent matrix is ​​provided with uniform drug-loading micropores, and the surface of the stent with uniform drug-loaded micropores is covered with therapeutic drugs-Rapa Mycin coating, the stent matrix is ​​a cylindrical network structure; the degradable zinc-based material is Zn-1%Mg-0.5%Ca alloy; the drug-loaded micropore size is 400-500nm, and the micropore depth is 180-240nm ; The thickness of the drug coating is 10 μm.

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Abstract

The invention relates to a degradable zinc-based micropore drug-loaded support and a preparation method thereof. The support comprises a degradable zinc-based material support matrix, uniform drug-loaded micropores are arranged on the surface of the support matrix, a therapeutic medicine coating covers the surface provided with uniform drug-loaded micropores, and the support matrix is in a cylinder net structure. The preparation method comprises the following steps: 1)processing the degradable zinc based material to the support matrix; 2)pretreating the surface of the support matrix; 3)performing electrolytic polishing processing on the support matrix; 4)performing corrosion processing on the support matrix after polishing; 5)pickling the support matrix after corrosion; and 6)coating a therapeutic medicine on the surface of the support matrix after aperture making. The support has good support performance after implantation for more than 4 months due to superior corrosion resistance of a zinc alloy matrix material, uniform micropores are distributed on the matrix surface, the therapeutic medicine layer is coated, so that medicine release can be controlled, support effect of the metal support can be fully performed, and the drug-loaded support has medical science curative effect with drug eluting support for inhibiting intimal hyperplasia to restenosis.

Description

technical field [0001] The invention relates to a biodegradable metal drug-eluting stent and a preparation method thereof, belonging to the technical field of implantable medical devices. Background technique [0002] In 1977, Gruentzing successfully performed the first case of percutaneous transluminal coronary angioplasty, which opened the era of simple balloon dilatation for cardiovascular treatment. This new technology without thoracotomy ended the dominance of coronary blood supply in cardiac surgery History of reconstruction. In 1987, Sigwart successfully implemented coronary artery stent surgery for the first time. A large number of clinical experiments confirmed that coronary artery stent implantation can effectively avoid the medical disadvantages of simple balloon expansion, and it was widely accepted as the second milestone in the history of interventional treatment of coronary heart disease. . After the coronary artery stent is implanted, it can maintain a supp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/02A61L31/16A61L31/14
Inventor 刘西伟蒲忠杰杨映红崔凯赵昆张昱昕杨明
Owner LEPU MEDICAL TECH (BEIJING) CO LTD
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