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A solid tumor combined therapeutic composition

A combination therapy and tumor therapy technology, applied in the field of cancer therapy, can solve the problems of lack of biomarkers, low efficacy, and high toxicity and side effects in healthy cells and tissues, and achieve the effect of inhibiting tumor growth and improving survival rate.

Active Publication Date: 2022-07-05
SUZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Radiotherapy and chemotherapy can reach all parts of the body and can also treat some metastatic tumors. However, because radiotherapy and chemotherapy are administered systemically, they have relatively large toxic and side effects on healthy cells and tissues.
3. Antibody therapy, using antibodies to specifically block immune checkpoints related to tumor growth, such as PD-1 molecules, to initiate the body’s anti-tumor immune response process to achieve anti-tumor effects. Although this method is effective, there are The diversity of antigenic epitopes has brought about certain limitations such as low overall effectiveness and difficulty for drugs to break through the blood-brain barrier and tumor microenvironment
However, the common challenge of current targeted tumor therapy is the lack of effective biomarkers, and the evaluation of the efficacy of new targeted drugs needs to be combined with the exploration of biomarkers in future clinical trials

Method used

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  • A solid tumor combined therapeutic composition
  • A solid tumor combined therapeutic composition
  • A solid tumor combined therapeutic composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 shRNA

[0025] 1. Experimental method

[0026] 1. siRNA library transfected cells

[0027] (1) Spread 1.5×10 evenly in each well of a 24-well plate 5 MC-38 cells.

[0028] (2) Prepare for transfection after 12 hours.

[0029] (3) 20uM of Simmp3 and 2.5μL of NC were mixed in 100μL of DMEM medium. Take another tube and mix 2 μL of Lipofectamine RNAiMAX with 100 μL of DMEM medium. Vortex for 3 s and then stand at room temperature for 5 min.

[0030] (4) The above two separate reagents were mixed together, vortexed for 3S, and then allowed to stand at room temperature for 15min.

[0031] (5) Add the incubated plasmid and transfection reagent and mix well.

[0032] (6) Change to fresh complete medium after 7-12h;

[0033] (7) After a total of 48 hours of culture, samples can be collected to verify the expression.

[0034] 2. Vesicular stomatitis virus VSV M51R Amplification and purification of

[0035] (1) Mass culture containing VSV M51R vero cells.

...

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PUM

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Abstract

The invention discloses a solid tumor combined treatment composition, the effective components at least include mmp3 antagonistic substance and oncolytic virus. The invention uses the mmp3 antagonistic substance and the oncolytic virus to treat solid tumors in combination, which can effectively inhibit the growth of the tumor and improve the survival rate.

Description

technical field [0001] The invention belongs to the technical field of cancer treatment, in particular to a solid tumor combined treatment composition. Background technique [0002] Tumor is a kind of disease that seriously endangers social and public health. According to statistics, in 2018, there were 18.1 million new tumor patients and 9.6 million deaths in the world. Therefore, exploring new and effective tumor treatments is one of the hotspots in global research. [0003] At present, the main methods of tumor treatment are as follows: 1. Surgical treatment. Surgical treatment can quickly and accurately remove tumor tissue to prevent its spread and metastasis. Currently, it is widely used. However, the limitation of surgical treatment is that it is only useful for early stage tumors. For advanced or metastatic tumors, surgery is difficult and the curative effect is poor. 2. Radiotherapy and chemotherapy, radiotherapy and chemotherapy are the use of physical and chemical...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/06A61K35/766A61K35/763A61K35/761A61K35/765A61K35/768A61K31/7105A61K31/18A61P35/00
CPCA61K45/06A61K35/766A61K35/763A61K35/761A61K35/765A61K35/768A61K31/7105A61K31/18A61P35/00A61K2300/00
Inventor 董春升熊思东胡静平梁明龙
Owner SUZHOU UNIV
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