Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Extraction method of schisandrin B extract

A technology of schisandrin and its extraction method, which is applied in the field of extraction of schisandrin extract, and can solve the problems of complex structural analogues, few sources of schisandrin, and low content of schisandrin

Active Publication Date: 2020-10-23
黑龙江澳利达奈德制药有限公司
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The development and application of schisandrin has important research value, but there are few sources of schisandrin, and it is mainly obtained by extraction and purification from schisandra medicinal materials, and the content of schisandrin from schisandra medicinal materials is relatively low, and the structural analogues are relatively complex. Therefore, it is of great research value to research and develop a preparation process that can be industrially prepared and isolated Schisandrin B

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Extraction method of schisandrin B extract
  • Extraction method of schisandrin B extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1: the selection of extraction pressure

[0040] 1.1 Weigh 5 parts of Schisandra powder of the same quality, 200g each, pass through a 40-mesh sieve, set the extraction temperature to 40°C, the extraction pressure to 15MPa, 20MPa, 25MPa, 30MPa, 35MPa, and the extraction time to 2h.

[0041] With the gradual increase of extraction pressure, the content of schisandrin B also gradually increased. This is because as the pressure increases, the supercritical CO 2 As the density increases, so does its solvency. When the extraction pressure increased from 15MPa to 30MPa, the content of schisandrin increased significantly. When the pressure reached 35MPa, although the content of schisandrin B increased, the increase was very small. Therefore, there is no linear correlation between the two, which may be related to the supercritical CO 2 about the compressibility. At low pressure, supercritical CO 2 High compressibility, high pressure, supercritical CO 2 Little ...

Embodiment 2

[0047] Embodiment 2: the selection of extraction temperature

[0048] 2.1 Weigh 5 parts of Schisandra powder of the same quality, 200g each, and pass through 40 sieves. The extraction pressure was controlled at 25MPa, the extraction temperatures were 20°C, 30°C, 40°C, 50°C, and 60°C, and the extraction time was 2h.

[0049] When the extraction temperature was lower than 40°C, the content of schisandrin increased with the increase of temperature. After the temperature reaches above 40°C, as the temperature rises, the content of schisandrin B decreases instead. This is because the vapor pressure and diffusion coefficient of the components to be separated are greatly increased when the temperature starts to rise, and the molecular motion is intensified. The solute and The chance of solvent association increases, thereby improving the solvency. However, when the temperature rises above 40°C, the CO 2 The density drops sharply, and increasing the volatility and diffusion coeffic...

Embodiment 3

[0055] Embodiment 3: the selection of raw material particle size

[0056] 3.1 Weigh 5 parts of schisandra powder of the same quality, 200 g each, and pass the schisandra powder through 20, 30, 40, 50 and 60 mesh sieves respectively. Control the extraction pressure at 25MPa, the extraction temperature at 40°C, and the extraction time at 2h.

[0057] When the particle size of the material is 40 mesh, the content of schisandrin B is the highest, and the particle size is too coarse or too fine, which is not conducive to supercritical CO 2extraction. When the particle size of the raw material increases from 20 mesh to 40 mesh, as the raw material particle becomes smaller, the mass transfer area between the material and the solvent increases gradually, which is beneficial to the dissolution of the ingredients. When the particle size of the raw material exceeds 40 mesh, the bulk density of the raw material in the extraction kettle increases greatly, making it difficult for the acti...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Meshaaaaaaaaaa
Login to View More

Abstract

The invention provides an extraction method of schisandrin B. Quality standards are formulated by taking schisandrin B as an index. The extraction method comprises three steps of CO2 supercritical extraction, silica gel column chromatography and hexane purification, and the content measured by an HPLC method is 25%-95%. The process is complete, low in cost and suitable for industrial popularization and application.

Description

technical field [0001] The invention belongs to the technical field of plant extraction, in particular to a method for extracting schisandrin B extract. Background technique [0002] Schisandra chinensis is the dry and mature fruit of Schisandra chinensis, a plant of the Magnoliaceae family. The lignans with biphenylcyclooctadiene structure in Schisandra chinensis are the main bioactive components, mainly including Schizandrin B, Schisandrin A, Schisandrin A, etc., and the content of Schisandrin B is generally 0.1-0.4 %between. [0003] According to ancient records, schisandra has the effects of regulating skin, beautifying the face, and prolonging life. "Shen Nong's Materia Medica" listed Schisandra as the top grade; "Compendium of Materia Medica" said that Schisandra "makes the body pleasing", and it is rich in nutrients and has the effect of ruddy complexion and fair skin. Li Shizhen said: Schisandra chinensis is difficult to memorize, and it is good to use the norther...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D317/70
CPCC07D317/70Y02P20/54
Inventor 周有财
Owner 黑龙江澳利达奈德制药有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com