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MiRNA for evaluating caffeic acid phenethyl ester cadmium-induced kidney injury resistance and application of miRNA

A caffeic acid phenethyl ester, kidney injury technology, applied in the field of miRNA markers, can solve the problems of low expression, no biological function reported in literature, etc.

Active Publication Date: 2020-11-13
SHANDONG AGRICULTURAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

It has been reported in the literature that miR-193a-3p inhibits breast cancer cell cycle progression and proliferation, and another report says that it is involved in inhibiting the growth of thyroid cancer cells; Kwon JE et al. Inhibit cell proliferation and promote apoptosis in cell lines; Wang HB et al. found low expression in lung cancer; other studies found that miR-193a-3p is involved in the occurrence and development of colorectal cancer, prostate cancer and hepatocellular carcinoma, but miR-193a The biological function of -3p in cadmium-induced kidney injury has not been reported in the literature

Method used

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  • MiRNA for evaluating caffeic acid phenethyl ester cadmium-induced kidney injury resistance and application of miRNA
  • MiRNA for evaluating caffeic acid phenethyl ester cadmium-induced kidney injury resistance and application of miRNA
  • MiRNA for evaluating caffeic acid phenethyl ester cadmium-induced kidney injury resistance and application of miRNA

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Experimental program
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Embodiment 1

[0038] Example 1: Evaluation of the protective ability of caffeic acid phenethyl ester (CAPE) against cadmium-induced renal injury

[0039] 1. Experimental method:

[0040] 1.1 Animal grouping and handling:

[0041] Six-week-old Kunming mice were selected and randomly divided into four groups, with 8 mice in each group. They were the blank control group and the cadmium injury group (CdCl 2 , 1.5mg / kg / day, intragastric administration), caffeic acid phenethyl ester alone treatment group (CAPE, 10μmol / kg / day, intragastric administration) and caffeic acid phenethyl ester protection group (CAPE, 10μmol / kg / day+CdCl 2 , 1.5mg / kg / day).

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Abstract

The invention discloses miRNA (micro Ribonucleic Acid) for evaluating caffeic acid phenethyl ester cadmium-induced kidney injury resistance and application of the miRNA. Research finds that the expression of miR-193a-3p is significantly increased in the kidney tissue subjected to cadmium-induced injury; therefore, the miR-193a-3p can be used as a marker to diagnose the situation of kidney injury of a cadmium-induced organism. Furthermore, the invention also finds that the expression of the miR-193a-3p can be remarkably reduced by intervening the kidney tissue subjected to cadmium-induced injury by using the CAPE. Therefore, it is judged that miR-193a-3p can be used as a miRNA marker for evaluating the cadmium-induced kidney injury resistance of CAPE. According to the invention, the application direction of CAPE is expanded, and a new way is opened up for deeply explaining the protection mechanism of CAPE on kidney injury induced by heavy metals such as cadmium and the like.

Description

technical field [0001] The invention relates to the technical field of miRNA markers, in particular to a miRNA for evaluating the resistance of phenethyl caffeate to cadmium-induced kidney damage and its application. Background technique [0002] Cadmium (Cd) is one of the heavy metals in the environment that are seriously harmful to human health. In recent years, with the rapid development of industry and agriculture and the increase in the number of Cd-containing products, the environmental pollution and human harm caused by Cd have attracted more and more attention. Cd can enter the human body through the digestive tract, respiratory tract and skin and cause damage to the digestive system, respiratory system, skeletal system, cardiovascular system, urinary system, endocrine system, blood system, and reproductive system. The kidney is the main accumulation site and target organ of Cd. Heavy metal Cd can directly cause damage to renal small blood vessels and renal tubules,...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6883C12Q2600/158C12Q2600/178
Inventor 李大鹏郝日礼
Owner SHANDONG AGRICULTURAL UNIVERSITY
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