Double-locking polymer and preparation method and application thereof
A polymer and lock-type technology, applied in the field of polymer fluorescent probes, to achieve good biocompatibility and degradability, and great potential for clinical application
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[0055] A kind of double lock polymer S-PPDPA-VC-Cy (synthetic route diagram sees figure 1 ), its preparation method comprises the following steps:
[0056] 1) Disperse 0.1 mol of diisopropylethanolamine, 0.1 mol of triethylamine and 0.001 mol of hydroquinone in 100 mL of tetrahydrofuran, then add 0.1 mol of methacryloyl chloride dropwise. Stir the reaction at room temperature under air atmosphere for 24h, remove the precipitated triethylamine hydrochloride by filtration, remove tetrahydrofuran by rotary evaporation, and distill under vacuum (0.05mmHg) at 85°C to obtain 2-(diisopropylamino)ethyl methacrylate (without color liquid);
[0057] 2) Add 0.4mmol of mPEG 114 Disperse in 20mL of anhydrous dichloromethane, then add 1.6mmol of 4-cyano-4-(thiophenylmethylthio)pentanoic acid and 0.2mmol of 4-dimethylaminopyridine, and then Add 10 mL of dicyclohexylcarbodiimide dichloromethane solution (containing 1.6 mmol of dicyclohexylcarbodiimide) dropwise, stir at room temperature fo...
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