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Double-locking polymer and preparation method and application thereof

A polymer and lock-type technology, applied in the field of polymer fluorescent probes, to achieve good biocompatibility and degradability, and great potential for clinical application

Active Publication Date: 2020-11-27
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it remains a challenge to develop nanoprobes that can simultaneously respond to orthogonal stimuli and have integrated imaging and therapeutic functions.

Method used

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  • Double-locking polymer and preparation method and application thereof
  • Double-locking polymer and preparation method and application thereof
  • Double-locking polymer and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0055] A kind of double lock polymer S-PPDPA-VC-Cy (synthetic route diagram sees figure 1 ), its preparation method comprises the following steps:

[0056] 1) Disperse 0.1 mol of diisopropylethanolamine, 0.1 mol of triethylamine and 0.001 mol of hydroquinone in 100 mL of tetrahydrofuran, then add 0.1 mol of methacryloyl chloride dropwise. Stir the reaction at room temperature under air atmosphere for 24h, remove the precipitated triethylamine hydrochloride by filtration, remove tetrahydrofuran by rotary evaporation, and distill under vacuum (0.05mmHg) at 85°C to obtain 2-(diisopropylamino)ethyl methacrylate (without color liquid);

[0057] 2) Add 0.4mmol of mPEG 114 Disperse in 20mL of anhydrous dichloromethane, then add 1.6mmol of 4-cyano-4-(thiophenylmethylthio)pentanoic acid and 0.2mmol of 4-dimethylaminopyridine, and then Add 10 mL of dicyclohexylcarbodiimide dichloromethane solution (containing 1.6 mmol of dicyclohexylcarbodiimide) dropwise, stir at room temperature fo...

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Abstract

The invention discloses a double-locking polymer and a preparation method and application thereof. The structural formula of the double-lock polymer is as shown in the specification; in the formula, xis a natural number ranging from 110 to 117, y is a natural number ranging from 70 to 80, and z is a natural number ranging from 1 to 3. The double-locking polymer has good biocompatibility and degradability, and nanoparticles formed by self-assembly of the double-locking polymer can be used for tumor imaging and treatment.

Description

technical field [0001] The invention relates to the technical field of polymer fluorescent probes, in particular to a double-lock polymer and its preparation method and application. Background technique [0002] Optical imaging is a visual imaging technology that uses the luminous intensity of luminescent probes as the detection signal, mainly including bioluminescence technology and fluorescence technology, and has been widely used in the early and accurate diagnosis of cancer. Activated fluorescent probes can send response signals to the tumor microenvironment, have low background noise and high signal-to-background ratio, and can perform sensitive and accurate diagnosis of tumors, and the effect is significantly better than that of "normally open" optical probes. Needle. [0003] In recent years, with the widespread application of prodrugs and nanotechnology in the field of drug delivery, the delivery strategies of anticancer drugs have been greatly enriched, and the sel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G65/333C08G65/334C08G65/332A61P35/00A61K49/00A61K47/69A61K47/60A61K41/00
CPCA61K41/0057A61K49/0034A61K49/0054A61K49/0093A61K47/60A61K47/6935A61P35/00C08G65/3322C08G65/33306C08G65/33327C08G65/33396C08G65/3348
Inventor 袁友永郑锐宗庆瑜肖炫姜茂麟
Owner SOUTH CHINA UNIV OF TECH
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