A kind of pharmaceutical composition of varenicline tartrate and preparation method thereof

A technology of varenicline tartrate and its mixture, which is applied in the direction of drug combinations, pharmaceutical formulas, and active ingredients of heterocyclic compounds. It can solve the problems of reduced dissolution rate of tablets, unsuitability for long-term use, and cumbersome process, and achieve high dissolution rate. , small brittleness, good fluidity
CN112057428BActive Publication Date: 2022-06-24SHANGHAI HANSOH BIOMEDICAL +2
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI HANSOH BIOMEDICAL
Publication Date
2022-06-24

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Abstract

The invention provides a varenicline tartrate composition and a preparation method thereof. In the composition, the weight percentage of sorbitol and microcrystalline cellulose is 5:1 to 10:1, and includes a disintegrant, a binder agents and lubricants. This product adopts the powder direct pressing process, the preparation process is simple, easy to operate, good reproducibility, and suitable for large-scale industrial production. Moreover, the varenicline tartrate composition prepared by the present invention not only does not need to control the particle size, but also has small friability, good fluidity, high dissolution rate, good stability and low probability of adverse reactions.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, in particular to a pharmaceutical composition of varenicline tartrate and a preparation method thereof. Background technique

[0002] Varenicline can specifically bind to acetylcholine receptors and is used to modulate cholinergic function. Accordingly, the compounds can be used to treat various diseases or conditions including, but not limited to, inflammatory bowel disease, irritable bowel syndrome, spastic dystonia, chronic pain, acute pain, vasoconstriction, anxiety, panic disorder, depression , bipolar disorder, autism, sleep disorders, jet lag syndrome, amyotrophic lateral sclerosis (ALS), cognitive impairment, hypertension, bulimia, anorexia, obesity, cardiac arrhythmias, hypersecretion of gastric acid , ulcers, pheochromocytoma, chemical dependence and addiction (eg, dependence or addiction to nicotine (and / or tobacco products), alcohol, benzodiazepines, barbiturates, opioids, ...

Claims

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