Microhaplotype composite amplification system in degradation sample analysis, and construction method thereof

A technology of compound amplification system and construction method, applied in the field of haplotype frequency, can solve the problems of STR typing technology can not obtain ideal typing results, allele loss, etc., and achieve the effect of high sensitivity and strong identification ability
CN112063723AActive Publication Date: 2020-12-11SHANXI MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANXI MEDICAL UNIV
Publication Date
2020-12-11

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Abstract

The invention provides a microhaplotype composite amplification system in degradation sample analysis, a construction method thereof and related haplotype frequency. The invention provides 23 microhaplotypes in total and rs numbers thereof in one group of genetic marker compositions. According to amplification primers of the 23 microhaplotypes, a microhaplotype composite amplification system for analyzing degradation samples is constructed. The invention also provides a kit comprising the amplification primers of the 23 microhaplotypes. The microhaplotype composite amplification system provided by the invention can be used for forensic identification of the degradation samples, and is high in sensitivity and strong in recognition capability.
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Description

technical field

[0001] The invention belongs to the field of forensic medicine, and in particular relates to a micro-haplotype composite amplification system in the analysis of degraded sample materials, a construction method thereof, and related haplotype frequencies. Background technique

[0002] Forensic physical evidence is mainly to solve the problem of personal identification in judicial practice. Personal identification is based on the same identification theory as the guiding principle, and scientifically identifies the genetic markers of on-site samples. Therefore, new, more stable, accurate, fast, and informative The development and utilization of a large number of human genetic markers has always been a hot spot in forensic research.

[0003] With the development of DNA analysis technology and its application in forensic science, people have gradually developed personal identification detection based on short tandem repeat (STR) length polymorphism and single nucl...

Claims

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