Therapeutic agent for inflammatory bowel disease
A technology of inflammatory bowel disease and therapeutic agent, which is applied in the field of therapeutic agent for inflammatory bowel disease, and can solve the problems of not knowing the therapeutic effect of 5-hydroxypyrimidine-4-carboxamide derivatives
Inactive Publication Date: 2020-12-11
DAIICHI SANKYO CO LTD
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- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
However, 5-hydroxypyrimidine-4-carboxamide derivatives are not known to have a therapeutic effect on inflammatory bowel disease
Method used
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Embodiment 1）
[0073] [({5-Hydroxy-2-[(1-{4'-[(2S)-2-hydroxypropyl]biphenyl-4-yl}piperidin-4-yl)methyl]-6-methyl Pyrimidin-4-yl}carbonyl)amino]acetic acid (Compound A)
[0074] Compound A was prepared according to the method of Example 45 of WO2011 / 049126.
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The purpose of the present invention is to provide a drug that contains a compound having an excellent therapeutic effect on inflammatory bowel disease. The therapeutic agent for inflammatory bowel disease contains as an active ingredient a compound represented by formula (I) [in general formula (I), R1 represents a hydroxy C1-C6 alkyl group, C2-C7 alkanoyl group, C2-C7 alkanoyl C1-C6 alkyl group,(C1-C6 alkoxy)carbonyl group, (C1-C6 alkoxy)carbonyl C1-C6 alkyl group, carboxy group, or carboxy C1-C6 alkyl group] or a pharmaceutically acceptable salt thereof.
Description
technical field [0001] The present invention relates to a therapeutic agent for inflammatory bowel disease comprising a 5-hydroxypyrimidine-4-carboxamide derivative as an active ingredient. Background technique [0002] Inflammatory bowel disease is a disease that causes chronic inflammation or ulceration of the mucosa of the large intestine and small intestine, and ulcerative colitis and Crohn's disease are representative diseases. Ulcerative colitis is a non-specific inflammatory disease of unknown etiology, mainly causing mucosal erosions and ulcers from the rectum to the large intestine. Crohn's disease is a disorder of unknown cause in which discontinuous chronic granulomatous inflammation occurs throughout the digestive tract from mouth to anus. [0003] In addition, noninfectious colitis, broadly defined as inflammatory bowel disease and showing pathological findings on the large bowel mucosa, includes: lymphocytic colitis, Behçet's disease, diverticulitis, diverticu...
Claims
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IPC IPC(8): A61K31/513A61P1/00A61P1/04A61P29/00
CPCA61P29/00A61K31/513A61P1/00A61P1/04A61K45/06A61P1/12A61K31/506
Inventor 丰嶋由纪
Owner DAIICHI SANKYO CO LTD