Medicinal use of NRK in lung cancer therapy and prognosis

A technology for lung cancer and prognosis, applied in the field of biomedicine, can solve the problems that NRK has not yet been found in the treatment and prognosis diagnosis of lung cancer, and the mechanism of NRK expression kinase activity and regulation of signaling cascades has not been elucidated.

Inactive Publication Date: 2020-12-18
GUANGXI MEDICAL UNIVERSITY
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Problems solved by technology

However, the expression of NRK in other tissues or cells, its substrates, and the mechanisms that regulate its kinase activity and regulate signaling cascades have not been elucidated
At present, the relevant medical application of NRK in the treatment and prognosis of lung cancer has not been found

Method used

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  • Medicinal use of NRK in lung cancer therapy and prognosis
  • Medicinal use of NRK in lung cancer therapy and prognosis
  • Medicinal use of NRK in lung cancer therapy and prognosis

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Embodiment Construction

[0036] In order to understand the above-mentioned purpose, features and advantages of the present invention more clearly, the technical solutions of the present invention will be described in further non-limiting detail below in conjunction with the accompanying drawings and specific embodiments.

[0037] 1. Materials and methods

[0038] Lung adenocarcinoma tissues and their corresponding non-malignant lung tissues (at least 5 cm away from the tumor) were collected prospectively from patients with primary lung adenocarcinoma diagnosed in the Cancer Hospital Affiliated to Guangxi Medical University. Selection criteria included: 1) pathological diagnosis of LUAD; 2) patients did not receive chemotherapy or radiotherapy before surgery; 3) patients had no history of other types of tumors; 4) patients had complete medical records. Patients who lacked AJCC staging information, lacked histological information, and died within 30 days after surgery or from other causes of disease wer...

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Abstract

The invention discloses medicinal use of NRK in lung cancer therapy and prognosis. The invention particularly discloses application of the NRK in preparation of products for diagnosing prognosis of alung cancer and application of the NRK in preparation of drugs for treating the lung cancer; and the invention relates to application of an NRK neutralizing antibody in preparation of products for diagnosing the lung cancer and application of the NRK neutralizing antibody in preparation of drugs for treating the lung cancer. According to the medicinal use, CAFs and NFs derived from tissue of LUADI, II and III are analyzed by using RNA-seq and a comprehensive bioinformatics method, it is discovered that the NRK is specifically expressed in lung-cancer-tumor-related fibroblasts, can serve as aclinical diagnosis biomarker of the lung cancer and can provide a better diagnosis prognosis index; and the NRK in LUAD-related CAFs is increased remarkably, so that the NRK can serve as a target point of combined treatment on LUAD.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the medical application of NRK in the treatment and prognosis diagnosis of lung cancer. Background technique [0002] Lung cancer is the leading cause of cancer death worldwide. Lung cancer is divided into small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), of which NSCLC accounts for 85% of all lung cancers. NSCLC is mainly divided into adenocarcinoma (LUAD), squamous cell carcinoma (LUSC) and large cell carcinoma. LUAD is the main subtype of NSCLC, accounting for about 50% of NSCLC. Although the rapid development of clinical treatment methods such as surgery, chemotherapy, targeted therapy, and immunotherapy have significantly improved the prognosis of lung cancer patients including LUAD, the prognosis of these patients is still poor due to drug resistance or poor response, and the 5-year The average survival rate is only 15%. In addition, most LUAD pat...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886G01N33/574G01N33/573A61K39/395A61P35/00
CPCA61K39/3955A61P35/00C12Q1/6886C12Q2600/118C12Q2600/158G01N33/573G01N33/57423G01N33/57496G01N2333/91215
Inventor 阳洁韦彤彤宋锦静莫孝成黎骊莫小香沈小菊陈罡黄志广
Owner GUANGXI MEDICAL UNIVERSITY
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