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Use of aurantio-obtusin in hair loss prevention and hair growth

A technology of orange cassiatin and hair loss, which is applied in the direction of medical preparations containing active ingredients, hair care, cosmetic preparations, etc.

Inactive Publication Date: 2020-12-25
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no literature publicly reporting the application of orange cassiatin in hair loss and hair growth

Method used

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  • Use of aurantio-obtusin in hair loss prevention and hair growth
  • Use of aurantio-obtusin in hair loss prevention and hair growth
  • Use of aurantio-obtusin in hair loss prevention and hair growth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1: Curative effect evaluation experiment of arurite cassiatin on natural hair growth model of C57BL / 6 mice

[0035] 1. Experimental animals

[0036] The experimental animals were male C57BL / 6, 8 weeks old, weighing 18-20g, purchased from the Comparative Medical Center of Yangzhou University. C57BL / 6 mice were reared under normal conditions, temperature 25±2°C, humidity 50%-70%, light and dark alternately for 12 hours, free to eat and drink, change corncob bedding every two days, and wait for them to adapt The experiments were started after 7 days in the rearing environment.

[0037] 2. Drug configuration

[0038] 4% chloral hydrate: 0.4g of chloral hydrate was dissolved in 10ml of normal saline, vortex centrifuged until completely dissolved, and prepared into 4% chloral hydrate solution.

[0039] 2.1 2.5% (O / W) orange cassiatin cream for external use, made from the following raw materials:

[0040] 400 parts by weight of orange cassiatin, 1000 parts by weigh...

Embodiment 2

[0055] Example 2: Curative effect evaluation experiment of aurantine cassiatin on C57BL / 6 mouse chemotherapy alopecia model

[0056] 1. Experimental animals

[0057] The experimental animals were male C57BL / 6, 8 weeks old, weighing 18-20g, purchased from the Comparative Medical Center of Yangzhou University. C57BL / 6 mice were reared under normal conditions, temperature 25±2°C, humidity 50%-70%, light and dark alternately for 12 hours, free to eat and drink, change corncob bedding every two days, and wait for them to adapt The experiments were started after 7 days in the rearing environment.

[0058] 2. Drug configuration

[0059] The configuration of 4% chloral hydrate is the same as above.

[0060] The orange cassiacin ointment configuration is the same as above.

[0061] The configuration of orange cassiacin oral suspension is the same as above.

[0062] Cyclophosphamide for injection: Dissolve 0.2g cyclophosphamide in 20ml normal saline, vortex centrifuge until complet...

Embodiment 3

[0076] Example 3: Curative effect evaluation experiment of arurite cassiatin on C57BL / 6 mouse androgenetic alopecia model

[0077] 1. Experimental animals

[0078] The experimental animal is C57BL / J6, 8 weeks old, weighing 18-20g, purchased from the Comparative Medical Center of Yangzhou University. C57BL / 6 mice were reared under normal conditions, temperature 25±2°C, humidity 50%-70%, light and dark alternately for 12 hours, free to eat and drink, change corncob bedding every two days, and wait for them to adapt The experiments were started after 7 days in the rearing environment.

[0079] 2. Drug configuration

[0080] The configuration of 4% chloral hydrate is the same as above.

[0081] The orange cassiacin ointment configuration is the same as above.

[0082] The configuration of orange cassiacin oral suspension is the same as above.

[0083] Testosterone propionate injection (1mL: 25mg, Guangzhou Baiyunshan Mingxing Pharmaceutical Co., Ltd.), diluted with edible oil...

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PUM

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Abstract

The invention provides a use of aurantio-obtusin and a physiologically acceptable salt or solvate thereof in the preparation of a skin application composition, and an application of the skin application composition in pharmaceutical preparations, cosmetics, nursing products and beauty products. The skin application composition and the further applied preparation can comprehensively and effectivelyaim at various reasons of hair loss, so that the metabolic condition of a demand object can be better balanced, the mental state of the demand object is adjusted to achieve better treatment, and nursing synergistic effects are achieved. The aurantio-obtusin active ingredient is high in safety and small in toxic and side effects, and thereby has wide application prospects in the fields of pharmaceutical preparations, cosmetics, nursing products, beauty products and the like.

Description

technical field [0001] The invention belongs to the field of compounds and preparations thereof, and specifically relates to the use of arurinine cassiatin in the preparation of anti-hair loss and hair growth preparations, and its further application in the fields of medicine, cosmetics, nursing products, beauty products and the like. Background technique [0002] Alopecia is the phenomenon of hair falling out. The process of normal people's metabolism is also accompanied by hair loss and regeneration, which is a normal biological metabolic phenomenon, but there are also pathological hair loss caused by various reasons, such as excessive pressure, staying up late, endocrine disorders, etc. Alopecia can be divided into mental alopecia, seborrheic alopecia (androgenetic alopecia), chemical alopecia, physical alopecia, nutritional alopecia, endocrine alopecia six kinds from classification. Among them, seborrheic alopecia, psychogenic alopecia and chemical alopecia caused after...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61P17/14A61K8/35A61Q7/00
CPCA61K31/122A61P17/14A61K8/355A61Q7/00
Inventor 吴亮刘宙冯陈杰蔡磊蔡溪云弋吴舒婷董昊郝园园陈佳敏刘玉琳朱俊霖徐佳怡曹毅眀吴晓明
Owner CHINA PHARM UNIV
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