Free space type Mueller OCT imaging system for full-automatic time division detection and imaging method

Abstract

The invention discloses a free space type Mueller OCT imaging system for full-automatic time division detection and an imaging method. Four optical channels with different polarization types, namely horizontal type, vertical type, 45-degree linear polarization type and right-handed circular polarization type, are arranged in a reference wall, and meanwhile, a sample wall realizes polarized light of the four states by using a software program to control a rotating wave plate of a precision rotating worktable; a software program is also used in the reference wall to control an optical switch toselect different channels in the reference wall, and polarized light of the channels returns to interfere with the polarized light scattered by the sample wall correspondingly, so that time division detection of polarization information is realized; and meanwhile, 16 element images of a Mueller matrix of a sample are reconstructed, so that the collection of complete polarization information is realized. According to the free space type Mueller OCT imaging system for full-automatic time division detection and the imaging method, full-automatic control is realized, image acquisition can be rapidly carried out, and the sampling rate is improved.

Description

technical field [0001] The invention relates to the fields of biomedicine and optics, in particular to a free-space Mueller OCT imaging system and an imaging method for full-automatic time-division detection. Background technique [0002] At present, biological imaging technologies mainly include: ultrasound imaging, X-ray imaging, magnetic resonance diffusion imaging technology and optical coherence tomography technology. Among them, ultrasonic imaging, X-ray imaging and other methods are easy to cause deformation to the tissue, and will damage the tissue structure. The imaging resolution of the tissue structure is not high, and it is impossible to observe the tiny structure in the tissue. The new optical coherence tomography technology is With the advantages of no damage and high resolution, it can perfectly image the tissue microstructure, especially a new polarized optical coherence tomography technology developed by the Mueller OCT imaging system on the basis of traditi...

AI Technical Summary

Problems solved by technology

[0003] The commonly used polarized OCT is to use the Jones matrix to derive the Mueller matrix to describe the structural characteristics of biological tissues, but this method cannot completely describe the polarization characteristics of biological samples, so it is very necessary to build a Mueller OCT system. The reference wall of the Mueller OCT system built by some teams uses an adjustable rotating wave plate, and manually adjusts the rotation angle of the rotating wave plate to change the polarization state. However, this manual adjustment method will reduce the acquisition rate. The experimental efficiency is greatly reduced, and the manual adjustment of the scale will produce errors, which will cause certain fluctuations in the change of the polarization state, resulting in deviations in the collected data. Therefore, a free-space Mueller OCT imaging system with fully automatic time-division detection is proposed. It is necessary that the four light beams of the reference wall of the system are independent, which are horizontal, vertical, 45-degree linearly polarized light and right-handed circularly polarized light. Each channel uses software to control the response of the optical switch to select the channel. The sample The wall also uses software to control the rotation of the precision rotary table to achieve these four polarization states, so that the entire system is automated and the acquisition rate is improved.

Images