Unlock instant, AI-driven research and patent intelligence for your innovation.

Radiosurgical neuromodlation close to critical structures

A key and neurological technology, applied in surgical navigation systems, radiation-sensitized materials, wave energy or particle radiation treatment materials, etc., can solve problems such as neurological deficits

Pending Publication Date: 2021-01-12
ZAP SURGICAL SYST INC
View PDF14 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it is technically difficult to achieve RM of precise regions of the brain, especially those adjacent to key anatomical structures of the brain, without irradiating and damaging the nearby anatomical structures
Radiation-induced changes to brain regions close to the target area are potentially dangerous because it may result in side effects from the procedure, such as neurological deficits, or may induce effects contrary to the intended goals of a particular radiation modulating procedure

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Radiosurgical neuromodlation close to critical structures
  • Radiosurgical neuromodlation close to critical structures
  • Radiosurgical neuromodlation close to critical structures

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0022] Radiation modulation (RM, radiosurgery neuromodulation) involves the use of radiation surgery to functionally alter neuronal activity without killing cells or causing damage. In the present invention, target regions of the brain (which may be circuit nodes or pathway nodes within brain circuits) are modulated in activity level while protecting nearby non-target critical structures from radiation. The critical structure may be close to but separate from the target area, or may be within the target area but have different aspects.

[0023] In one aspect, the radiosensitizer is deposited in the brain regions one wishes to modulate, while the radioprotectant is deposited in those brain regions one wishes to prevent from being altered. Deposition of radiosensitizing and / or radioprotecting substances can be performed in various ways, for example, by one or more of the following two methods: 1) For example using MRI-guided focused ultrasound, often in combination with systemic...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Methods of treatment and treatment systems for performing radiomodulatory stereotactic radiosurgery to treat brain disorders in which target neural tissues associated with the brain disorder are sensitized to radiation by administration of a molecular substance and / or non-targeted critical structures are protected from radiation by a molecular substance, in order to treat disorders of brain circuitry. Specific embodiments disclose means for treating pain, obesity and drug addiction.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit under 35 USC § 119(e) of US Provisional Application No. 62 / 678,098, filed May 30, 2018, the entire disclosure of which is hereby incorporated by reference in its entirety for all purposes. [0003] This application is generally related to the following U.S. patents and applications: U.S. Patent No. 8,337,382 issued December 25, 2012; U.S. Patent No. 8,747,292 issued June 10, 2014; U.S. Patent No. 8,747,292 issued November 7, 2017 No. 9,808,651; and PCT Application PCT / US2017 / 054880, filed October 3, 2017; each of which is hereby incorporated by reference in its entirety for all purposes. This application is also generally related to the following publication: "Pharmacokinetic analysis and drug delivery efficiency of the focused ultrasound-induced blood-brain barrier opening in non-human primates" by Samiotaki et al. Open Pharmacokinetic Analysis and Drug Delivery Efficiency), Magn Reson...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61N7/02A61B34/10A61B34/20A61K9/00A61K41/00A61N5/10
CPCA61M37/0092A61N2005/1098A61N5/1084A61K41/0038A61N5/1031A61K51/0497
Inventor 小约翰·R·阿德勒M·B·施奈德
Owner ZAP SURGICAL SYST INC