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Preservative specific adsorption porous gel as well as preparation method and application thereof

A multi-channel, antiseptic technology, applied in the field of materials, to reduce the risk of adverse reactions and achieve the effect of rapid adsorption

Active Publication Date: 2021-01-15
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

All countries have stipulated the maximum allowable amount of paraben preservatives in cosmetics, but controlling the amount cannot fundamentally solve the adverse reactions caused by paraben preservatives to users

Method used

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  • Preservative specific adsorption porous gel as well as preparation method and application thereof

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Experimental program
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preparation example Construction

[0027] The invention provides a preparation method of preservative-specific adsorption porous gel, comprising the following steps:

[0028] 1) In the reactor, add the monomer solution, and then add the crosslinking agent sequentially while stirring to obtain a mixed solution;

[0029] 2) Nitrogen gas is passed into the mixed solution to remove dissolved oxygen in the mixed solution, then an initiator is added, and then injected into a mold and then polymerized under the condition of cutting off oxygen to obtain a porous gel;

[0030] 3) The suspension is taken out from the reactor, washed with distilled water, and dried to obtain a preservative-specific adsorption porous gel.

[0031] Specifically, the present invention first mixes the monomer solution and the crosslinking agent to obtain a mixed solution. In the present invention, the monomer solution used is selected from hydroxyethyl methacrylate, N-vinylpyrrolidone, cyclohexyl methacrylate, N,N-dimethylacrylamide and silo...

Embodiment 1

[0037] Preparation of thermally polymerized hydroxyethyl methacrylate / 4-vinylpyridine (HEMA / VP) porous gels:

[0038](1) After mixing 4 g of hydroxyethyl methacrylate and 2 g of 4-vinylpyridine, 0.6 g of cross-linking agent polyethylene glycol dimethacrylate was added while stirring to obtain a mixed solution.

[0039] (2) Introduce nitrogen into the mixed solution to remove the dissolved oxygen therein, then add 0.06g initiator azobisisobutyronitrile, then inject it into a mold with a 0.5mm steel wire fixed thereon, isolate oxygen, and carry out at 65°C After thermal polymerization for 24 hours, a solidified porous gel was obtained.

[0040] (3) The multi-channel gel was taken out from the mold, washed with distilled water, and dried to obtain a HEMA / VP multi-channel gel.

Embodiment 2

[0042] Preparation of photopolymerizable hydroxyethyl methacrylate / 4-vinylpyridine (HEMA / VP) porous gels:

[0043] (1) After mixing 4g of hydroxyethyl methacrylate and 2g of 4-vinylpyridine, add 0.6g of cross-linking agent polyethylene glycol dimethacrylate while stirring to obtain a mixed solution.

[0044] (2) Nitrogen is passed into the mixed solution to remove dissolved oxygen therein, and then 0.04g initiator 2-p-hydroxyl-2-methyl-1-phenyl-1-acetone is added, and then injected into a fixed 0.5mm steel wire In the mold, oxygen is isolated, and at room temperature, 365nm ultraviolet rays are irradiated for 15 minutes to obtain a solidified porous gel.

[0045] (3) The multi-channel gel was taken out from the mold, washed with distilled water, and dried to obtain a HEMA / VP multi-channel gel.

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Abstract

The invention belongs to the technical field of materials, and discloses preservative specific adsorption porous gel as well as a preparation method and application thereof. The preservative specificadsorption porous gel is synthesized by adopting a monomer polymerization method. The preparation method comprises the following steps of 1) adding a monomer solution into a reactor, and adding a cross-linking agent while stirring to obtain a mixed solution; 2) introducing nitrogen into the mixed solution to remove dissolved oxygen in the mixed solution, adding an initiator, injecting the mixed solution into a mold, and carrying out a polymerization reaction under the condition of oxygen isolation to obtain cured porous gel; and 3) taking out the porous gel from the mold, cleaning the porous gel with distilled water, and drying the porous gel to obtain the preservative specific adsorption porous gel. The preservative specific adsorption porous gel prepared by the preparation method can quickly adsorb nipagin ester preservatives in cosmetics to reduce the content of the nipagin ester preservatives by 90% or above, and has a relatively small adsorption effect on active ingredients in thecosmetics.

Description

technical field [0001] The invention relates to the field of material technology, in particular to a preservative-specific adsorption porous gel and a preparation method and application thereof. Background technique [0002] Cosmetics are a class of chemical industrial products that are spread on the surface of the human body by smearing, spraying or other similar methods to achieve the purpose of cleaning, eliminating bad temperature, skin care, beauty and modification. Cosmetics, especially cosmetics with high water content, may be polluted by microorganisms during production, storage and use, resulting in deterioration, causing harm to the human body and losing their use value. At present, the methods to avoid microbial contamination in cosmetics are: [0003] (1) Add preservatives. Preservatives act on the cell membrane, cell wall or organelles of microorganisms to destroy cell proliferation and division, inhibit the growth and reproduction of microorganisms, and thus ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/37A61K8/81A61K8/73A61K8/67A61Q19/00
CPCA61K8/37A61K8/817A61K8/735A61K8/675A61Q19/00A61K2800/524A61K2800/10
Inventor 朱强
Owner NANTONG UNIVERSITY