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Method for determining content of chloride in compound polyethylene glycol electrolyte powder

A polyethylene glycol and determination method technology, applied in chemical method analysis, measuring device, chemical analysis by titration method, etc., can solve the problems of many influencing factors, complex components, and difficult observation

Pending Publication Date: 2021-02-05
四川健能制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The composition of this product is complex, and there are many factors affecting the determination
According to the imported drug registration standard JX20170714 of Compound Polyethylene Glycol Electrolyte Powder (Ⅲ), there is no obvious titration end point, which is difficult to observe

Method used

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  • Method for determining content of chloride in compound polyethylene glycol electrolyte powder
  • Method for determining content of chloride in compound polyethylene glycol electrolyte powder
  • Method for determining content of chloride in compound polyethylene glycol electrolyte powder

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Experimental program
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Effect test

Embodiment Construction

[0011] For confirming the effect of assay method of the present invention, inventor has carried out a large amount of experiments, and has carried out scientific verification to finally determined assay method, verification experiment is as follows:

[0012] specificity test

[0013] Blank solvent: water

[0014] Test solution: Take 1 bag of this product, put it in a 1000ml measuring bottle, add an appropriate amount of water, dissolve it by ultrasonic, add water to dilute to the mark, and shake well.

[0015] Blank excipient solution: Accurately weigh about 71.5g of the prescription blank excipient without sodium chloride and potassium chloride, put it in a 1000ml measuring bottle, add an appropriate amount of water to dissolve, add water to dilute to the mark, and shake well.

[0016] Accurately measure 50ml each of blank solvent, blank excipient solution and test solution, put them in a conical flask, add 1 drop of phenolphthalein indicator, 5ml of 2% dextrin solution, 2ml...

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Abstract

A fluorescein indicator and a silver precipitation method are selected to determine the content of chloride in s compound polyethylene glycol electrolyte powder, and dilute sulfuric acid is used to eliminate the interference of sodium bicarbonate in the compound polyethylene glycol electrolyte powder. A proper amount of a sample solution is taken, and is put into a conical flask, 1 drop of a phenolphthalein indicator, 5 ml of a 2% dextrin solution, 2 ml of a 2.5% borax solution and a proper amount of dilute sulfuric acid are added to disappear red, 5-8 drops of a fluorescein indicator solutionare added, and titrating is carried out with a silver nitrate titrating solution (0.1 mol / L) until the fluorescence color of the solution fades and becomes light pink.

Description

technical field [0001] The invention relates to a method for determining chloride content in compound polyethylene glycol electrolyte powder. The method adopts a silver precipitation method to determine the chloride content in compound polyethylene glycol electrolyte powder. Background technique [0002] The silver precipitation method is a titration analysis method based on the precipitation reaction. Precipitation titration must meet the following conditions: 1. The solubility is small, and can be quantitatively completed; 2. The reaction speed is large; 3. There is an appropriate indicator to indicate the end point; 4. The adsorption phenomenon does not affect the observation of the end point. [0003] The compound polyethylene glycol electrolyte powder is a compound preparation, which is composed of the raw material polyethylene glycol 4000, sodium chloride, potassium chloride, sodium bicarbonate, sodium sulfate and auxiliary material sodium saccharin. The composition o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N31/16G01N21/83
CPCG01N21/83G01N31/162
Inventor 唐检珍刘萍龚太权
Owner 四川健能制药有限公司
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