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Mesenchymal stem cell and therapeutic agent for neuropathy

A stem cell source technology, applied to nervous system diseases, animal cells, vertebrate cells, etc., can solve the problems of substances that have not shown the effect of protecting nerve cells, and cannot inhibit the reduction of nerve cells

Pending Publication Date: 2021-02-12
ROHTO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Drugs such as donepezil for Alzheimer's disease and levodopa for Parkinson's disease are designed to restore the information processing function of the neural network caused by the reduction of nerve cells by supplementing chemical transmitter signals, which cannot Inhibition of nerve cells reduces itself
In addition, among the existing therapeutic drugs for neurodegenerative diseases and strokes, there is no substance that shows the effect of protecting nerve cells

Method used

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  • Mesenchymal stem cell and therapeutic agent for neuropathy
  • Mesenchymal stem cell and therapeutic agent for neuropathy
  • Mesenchymal stem cell and therapeutic agent for neuropathy

Examples

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preparation example Construction

[0053] (Method for preparing mesenchymal stem cells)

[0054]Any one or both of HGF, SHH, OLIG2, VEGFA, NEUROG1, GRPR, IL1R1, CRHR2, CCKAR, APOE, PAX3, PAX5, EGF, CXCL1, GDNF, NRCAM, DLL1, HEYL, BMP2, NTN1, ASCL1, NRP2 The method for preparing the above-mentioned highly expressed mesenchymal stem cells is not particularly limited, for example, it can be prepared in the following manner. That is, those skilled in the art can isolate and culture mesenchymal stem cells from tissues such as fat, umbilical cord, and bone marrow according to known methods, and use , PAX3, PAX5, EGF, CXCL1, GDNF, NRCAM, DLL1, HEYL, BMP2, NTN1, ASCL1 or NRP2 specific binding antibody, use cell sorter, magnetic beads, etc. to separate HGF, SHH, OLIG2, VEGFA, NEUROG1, GRPR, IL1R1, CRHR2, CCKAR, APOE, PAX3, PAX5, EGF, CXCL1, GDNF, NRCAM, DLL1, HEYL, BMP2, NTN1, ASCL1 or NRP2 high-expression cells were isolated and obtained. In addition, HGF, SHH, OLIG2, VEGFA, NEUROG1, GRPR, IL1R1, CRHR2, CCKAR, APOE, ...

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Abstract

The purpose of the present invention is to provide a novel therapeutic agent for neuropathy. For this purpose, provided is a mesenchymal stem cell characterized in that one or more members selected from among HGF, SHH, OLIG2, VEGFA, NEUROG1, GRPR, IL1R1, CRHR2, CCKAR, APOE, PAX3, PAX5, EGF, CXCL1, GDNF, NRCAM, DLL1, HEYL, BMP2, NTN1, ASCL1 and NRP2 are highly expressed therein.

Description

technical field [0001] The present invention relates to mesenchymal stem cells and therapeutic agents for neuropathy. Background technique [0002] Neurodegenerative diseases, which are disorders of nerve cells of the brain, continue to increase year by year as the aging society progresses. Examples of neurodegenerative diseases include Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), spinocerebellar degeneration, and the like. In Alzheimer's disease, nerve cells in the cerebral cortex, hippocampus and other parts fall off, and memory declines. In addition, in Parkinson's disease, nerve cells located in a part called the substantia nigra are shed, and motor function is impaired. Furthermore, other than neurodegenerative diseases, cerebral infarction and cerebral hemorrhage due to cerebral apoplexy are known as diseases caused by disorders of nerve cells in the brain. [0003] In addition, neonatal brain damage in the perinatal period occurs a...

Claims

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Application Information

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IPC IPC(8): C12N5/0775A61K35/28A61K35/51A61P25/00
CPCA61K35/51A61P25/00A61K35/28
Inventor 石川格靖堀内阳子泷尻崇史黑木辉汤本真代
Owner ROHTO PHARM CO LTD
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