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Glucose-responsive insulin

An insulin and halogen technology, applied in the direction of insulin, hormone peptides, organic active ingredients, etc., can solve the problems of enhancing blood sugar control, difficult to achieve, etc.

Pending Publication Date: 2021-02-26
UNIV OF UTAH RES FOUND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While insulin glargine has long-term benefits, adding glucose-responsive properties to enhance glycemic control while also preventing iatrogenic hypoglycemia remains elusive

Method used

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  • Glucose-responsive insulin
  • Glucose-responsive insulin
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Embodiment Construction

[0030] The disclosed methods and compositions can be understood more readily by reference to the following detailed description of particular embodiments and Examples included therein, and to the accompanying drawings and their preceding and following descriptions.

[0031] It is to be understood that, unless otherwise indicated, the disclosed methods and compositions are not limited to specific synthetic methods, specific synthetic techniques, or specific reagents, and as such may vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting.

[0032]The present invention discloses materials, compositions and components useful in, in combination with, in the manufacture of, or products and compositions of the disclosed methods. These and other materials are disclosed herein, and it is understood that when combinations, subsets, interactions, groups, etc., of these materials ar...

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Abstract

The present disclosure is concerned with insulin-based peptides, methods of making the peptides, and methods of treating diabetes using these peptides. This abstract is intended as a scanning tool forpurposes of searching in the particular art and is not intended to be limiting of the present invention.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Application No. 62 / 658,372, filed April 16, 2018, which is hereby incorporated by reference in its entirety. [0003] Sequence Listing Citation [0004] The sequence listing was filed on April 15, 2019 as a text file named "21101_0369P1_ST25.txt" and 3080 bytes in size, created on April 15, 2019 pursuant to 37 C.F.R. §1.52(e)(5 ) is incorporated herein by reference. Background technique [0005] Since the discovery of insulin nearly a century ago, many advances in insulin design have allowed people with diabetes to improve their glycemic control; however, the risk of hypoglycemia remains a major obstacle to strict glycemic control (Brownlee and Hirsch (2006) JAMA: The Journal of the American Medical Association 295(14):1707-8; Frier, B.M. (2014) Nature Reviews Endocrinology 10(12):711). One problem is that commercially available insulin analogs do not modulate biological activ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61K31/69A61K38/16A61K38/17A61K38/28A61P3/08A61P3/10C07K14/435C07K14/47C07K14/62
CPCA61K31/69A61P3/10C07K14/62A61K38/00A61K47/54
Inventor D·H-C·周
Owner UNIV OF UTAH RES FOUND