High performance liquid chromatography-quadrupole time-of-flight mass spectrometry detection method for electronic cigarette tobacco juice non-targeting analysis

Abstract

A high performance liquid chromatography quadrupole time-of-flight mass spectrometry detection method for electronic cigarette tobacco juice non-targeted analysis comprises: diluting electronic cigarette tobacco juice with a solvent and then filtering through an organic phase filter membrane, taking filtrate for analysis, separating a sample through a liquid chromatographic column and then entering a quadrupole time-of-flight mass spectrometry for measurement, and realizing non-targeted analysis of the chemical components in the electronic cigarette liquid. The high performance liquid chromatography quadrupole time-of-flight mass spectrometry technology is applied to the non-targeting analysis of the electronic cigarette liquid for the first time, the problem of chromatographic peak analysis is solved by utilizing the characteristic of high resolution of the time-of-flight mass spectrometry, and the chemical components of a complex sample of the electronic cigarette liquid can be conveniently, quickly, accurately and comprehensively analyzed; and a reliable, stable and brand-new method is provided for style characteristic analysis and quality safety monitoring of the electronic cigarette liquid.

Description

technical field [0001] The invention belongs to the technical field of physical and chemical testing of electronic cigarette products, and in particular relates to a high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry detection method for non-target analysis of electronic cigarette liquid. Background technique [0002] E-cigarette is the fastest-growing new tobacco product in recent years. It is a product that transmits nicotine and other substances in e-cigarette liquid to the respiratory system through means such as nebulizer atomization. As the core of electronic cigarettes imitating traditional cigarettes, e-cigarette liquid is usually a mixture of solvents (propylene glycol or glycerin), nicotine and various flavors and fragrances that improve the taste. In order to achieve special effects and meet the hobbies and needs of different smokers, some e-cigarette liquids are also added with tobacco extracts, tea extracts, Chinese herbal medicin...

AI Technical Summary

Problems solved by technology

Due to the complexity of the composition of e-cigarette liquids, restricted by sample matrix interference and insufficient detector sensitivity, the number of chemical components covered by conventional targeting methods is relatively limited, and generally requires specific or even cumbersome sample pretreatment techniques. Conducive to a comprehensive and systematic understanding of the chemical composition of e-cigarette liquid

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