Coupled chimeric antigen receptor cells and uses thereof

Abstract

The invention relates to coupled chimeric antigen receptor cells and uses thereof. The invention relates to a modified cells comprising a nucleic acid sequence encoding an antigen binding molecule, the sequence further comprises an antigen binding domain, a transmembrane domain, and an intracellular signal transduction domain wherein the intracellular signal transduction domain comprises at leastone of TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, MYD88, TRIF, TRAM, or TRAP.

Description

Technical field [0001] The present disclosure belongs to the field of biomedical technology, and involves cells, compositions, and methods of treating diseases including cancer using coupling antigens receptor cytometry. Background technique [0002] Tumor cell immunotherapy has now achieved great results, but cell therapies are still difficult to treat certain malignant tumors, and in certain treatments have also caused side effects. The latest developments in genome editing technologies allow scientists to edit gene expression in cells to enhance effector function or bypass tumor immunosuppressive tumor microenvironment. Therefore, there is a need to regulate the intracellular signal conduction domain to enhance cell immunotherapy of tumors. Inventive content [0003] The present disclosure relates to modified cells comprise a nucleic acid sequence encoding an antigen binding molecule, the sequence further comprising an antigen binding domain, a transmembrane domain, and an in...

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Problems solved by technology

[0002] Cellular immunotherapy of tumors has achieved great results, but cell therapy is s

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