Antibacterial hemostatic healing-promoting gel, preparation method and application thereof

A technology of gel and original gum, which is applied in medical formula, medical science, bandages, etc., can solve the problems of easy inflammation, poor hemostasis effect, wound damage, etc., so as to facilitate tissue growth, protect wound nerves, and promote wound healing. healing effect

Inactive Publication Date: 2021-03-23
苏州举健生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still the following problems: the current hemostatic materials have single effects, narrow application areas, do not have good elasticity and air permeability, are easy to cause adverse reactions such

Method used

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  • Antibacterial hemostatic healing-promoting gel, preparation method and application thereof
  • Antibacterial hemostatic healing-promoting gel, preparation method and application thereof
  • Antibacterial hemostatic healing-promoting gel, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] An antibacterial gel for hemostasis and promoting healing and a preparation method thereof, an antibacterial gel for hemostasis and promoting healing, calculated in parts by mass, the raw material of the gel includes: 4 parts of carboxylic acid or sodium salt of carboxylic acid with active double bonds, with 10 parts of amide with active double bond, 1 part of aldehyde with active double bond, 30 parts of fish collagen peptide, 3 parts of heparin sodium; 1 part of modified guanidine salt with active double bond, 3 parts of chitosan, 1 part of modified diamine with active double bond, 0.4 part of double bond cross-linking agent, 7 parts of L-arginine, 50 parts of aloe gum, 5 parts of β-sodium glycerophosphate, 600 parts of deionized water.

[0025] As a preferred embodiment of the present invention, the carboxylic acid or sodium carboxylic acid salt with active double bonds is any one of acrylic acid, sodium acrylate, methacrylic acid, sodium methacrylate, undecylenic aci...

Embodiment 2

[0037] An antibacterial hemostatic and healing-promoting gel and a preparation method thereof, an antibacterial hemostatic and healing-promoting gel, calculated in parts by mass, the raw materials of the gel include: 12 parts of carboxylic acid or sodium carboxylic acid salt with active double bonds, with 6 parts of amide with active double bond, 2 parts of aldehyde with active double bond, 70 parts of fish collagen peptide, 2.5 parts of heparin sodium; 3 parts of modified guanidine salt with active double bond, 6 parts of chitosan, 3 parts of modified diamine with active double bonds, 0.6 parts of double bond cross-linking agent, 6 parts of L-arginine, 150 parts of aloe gum, 7 parts of β-sodium glycerophosphate, 400 parts of deionized water.

[0038] As a preferred embodiment of the present invention, the carboxylic acid or sodium carboxylic acid salt with active double bonds is any one of acrylic acid, sodium acrylate, methacrylic acid, sodium methacrylate, undecylenic acid, ...

Embodiment 3

[0050] An antibacterial hemostatic and healing-promoting gel and a preparation method thereof, an antibacterial hemostatic and healing-promoting gel, calculated in parts by mass, the raw materials of the gel include: 18 parts of carboxylic acid or sodium carboxylic acid salt with active double bonds, with 2 parts of amide with active double bond, 3 parts of aldehyde with active double bond, 100 parts of fish collagen peptide, 2 parts of heparin sodium; 5 parts of modified guanidine salt with active double bond, 10 parts of chitosan, 5 parts of modified diamine with active double bond, 0.8 part of double bond crosslinking agent, 4 parts of L-arginine, 200 parts of aloe gum, 10 parts of β-sodium glycerophosphate, 200 parts of deionized water.

[0051] As a preferred embodiment of the present invention, the carboxylic acid or sodium carboxylic acid salt with active double bonds is any one of acrylic acid, sodium acrylate, methacrylic acid, sodium methacrylate, undecylenic acid, an...

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Abstract

The invention provides antibacterial hemostatic healing-promoting gel, a preparation method and an application thereof. The gel is prepared from the following raw materials: 4-18 parts of carboxylic acid or sodium carboxylate with active double bonds, 2-10 parts of amide with active double bonds, 1-3 parts of aldehyde with active double bonds, 30-100 parts of fish collagen peptide and 2-3 parts ofheparin sodium; and 1-5 parts of modified guanidine salt with active double bonds, 3-10 parts of chitosan, 1-5 parts of modified diamine with active double bonds, 0.4-0.8 part of a double bond cross-linking agent, 4-7 parts of L-arginine, 50-200 parts of aloe raw gel, 5-10 parts of sodium beta-glycerophosphate and 200-600 parts of deionized water. The antibacterial hemostatic healing-promoting gel has multiple wound healing effects, promotes skin capillary generation, facilitates tissue growth, protects wound nerves, achieves a hemostatic effect by quickly plugging damaged blood vessels, hasexcellent antibacterial property, and forms a protective isolation layer at a wound part to facilitate antibacterial hemostasis and healing promotion of a wound.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to an antibacterial hemostatic and healing-promoting gel, a preparation method and an application thereof. Background technique [0002] In daily work and life, people will inevitably cause injuries and bleeding wounds. The body's physiological hemostasis alone is far from achieving rapid and effective hemostasis. Therefore, it is necessary to introduce exogenous substances to accelerate wound hemostasis. Hemostatic materials have always been a research hotspot in the field of biomedicine. Traditional hemostatic materials tend to adhere to the wound surface, and when removed, it is likely to damage the newly recovered wound surface again. The current frontier hotspot is absorbable hemostatic materials. At present, the main domestic and foreign Absorbable hemostatic materials include fibrin glue, gelatin, collagen, oxidized cellulose, chitosan, and calcium alginate. Due to poor r...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0033A61L26/0023A61L26/0057A61L26/008A61L26/0061A61L2400/04C08L5/08C08L5/10
Inventor 梁晓飞宋萍周健
Owner 苏州举健生物科技有限公司
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