Blood fat adsorbent and preparation method thereof

A technology of adsorbent and blood lipid, which is applied in the field of blood lipid adsorbent and its preparation, can solve the problems of low reaction efficiency, inability to obtain blood lipid adsorbent, and low utilization rate of ligand, so as to improve adsorption efficiency, improve catalytic ring-opening and coupling The effect of improving the efficiency of the coupling reaction and the efficiency of the coupling reaction
CN112569909AActive Publication Date: 2021-03-30WUHAN RUIFA MEDICAL DEVICES CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WUHAN RUIFA MEDICAL DEVICES CO LTD
Publication Date
2021-03-30

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Abstract

The invention provides a blood fat adsorbent and a preparation method thereof. The method comprises the following steps: firstly, carrying out activation reaction on an adsorption carrier to obtain anepoxy group-containing activated carrier; then adding a blood fat adsorption ligand into a glycine-sodium hydroxide buffer solution to obtain a ligand solution; mixing the obtained epoxy group-containing activated carrier with a tertiary amine reagent, then adding the mixture into a ligand solution, mixing and stirring to carry out a coupling reaction, and after the reaction is completed, carrying out solid-liquid separation, cleaning and drying to obtain the blood fat adsorbent. According to the invention, the tertiary amine reagent is added into the coupling reaction system, the tertiary amine reagent is firstly adsorbed on the surface of the epoxy group-containing activated carrier, and then the coupling reaction is carried out in the glycine-sodium hydroxide buffer solution ligand solution, so that the coupling reaction efficiency and the ligand utilization rate can be improved, the adsorption efficiency of the adsorbent is improved, and the production cost is reduced.
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Description

technical field

[0001] The invention relates to the technical field of preparation of medical materials, in particular to a blood lipid adsorbent and a preparation method thereof. Background technique

[0002] Hyperlipidemia is a condition in which one or more lipids in the plasma are higher than normal due to abnormal fat metabolism or operation Lipoprotein is too low, which is called "dyslipidemia" in modern medicine. Hyperlipidemia is a common and frequently-occurring disease, and it is also the culprit of cardiovascular and cerebrovascular diseases. The damage to the body is hidden, gradual, progressive and systemic. Its direct damage is to accelerate systemic atherosclerosis. . Among them, low-density lipoprotein is a lipoprotein particle that carries cholesterol into peripheral tissue cells. When low-density lipoprotein is excessive, the cholesterol it carries will accumulate on the arterial wall, which is easy to cause atherosclerosis for a long time. Therefore, LD...

Claims

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