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Anaerostipes hadrus for use in promoting health

A healthy, bacteriological technique, applied in the field of Anaerostipeshadrus, capable of solving problems such as deficiencies

Inactive Publication Date: 2021-05-04
SECOND GENOME +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although many current therapies target inflammation, the lack of therapies that promote mucosal healing presents an opportunity for novel therapies that promote epithelial repair and intestinal barrier integrity

Method used

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  • Anaerostipes hadrus for use in promoting health
  • Anaerostipes hadrus for use in promoting health
  • Anaerostipes hadrus for use in promoting health

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0166] This example demonstrates the analysis of microbiota from healthy versus diseased subjects to identify a significantly increased prevalence of A. hadrus in healthy subjects compared to subjects with IBD.

[0167] A. method

[0168] Research Design and Sampling

[0169] The study and sample collection were approved by the Clinical Research Ethics Committee of University College Cork Teaching Hospitals. All participating individuals provided informed consent before gastrointestinal examinations were performed at Cork University Hospital or Bon Secours Hospital in Cork, Ireland. Diagnosis of CD or UC and inflammatory status is based on macroscopic examination of the GI tract during standard clinical colonoscopy. Adults (>=18 years old) who were routinely monitored and not diagnosed with any digestive disease or syndrome were considered as healthy controls. Biopsy samples were obtained from inflamed tissue from adult IBD patients or healthy tissue from control subjects...

Embodiment 2

[0194] Use of A. hadrus for treating inflammatory bowel disease

[0195] In this example, the glucose tolerance test (GTT) was performed on a high-fat diet-induced obese mouse model to study the effect of administering live bacteria on glucose homeostasis. Mice were prepared and used as described in WO2019067087 (which is incorporated herein by reference in its entirety).

[0196] IBD was induced in mice by supplementing drinking water with 3% sodium dextran sulfate for 7 days. For each daily treatment, A. hadrus liquid cultures were grown to an optical density of 0.4–0.5 and then pelleted by centrifugation. Bacteria were resuspended in phosphate-buffered saline and mice were administered 100 μl by oral gavage starting on day 8. Mice were treated daily for 1 week with A. hadrus suspension or phosphate-buffered saline alone as negative controls. Five days after bacterial treatment, live mice were scored for colitis using endoscopy. Endoscopic injury scores were determined b...

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Abstract

The present disclosure relates to live biotherapeutic products, probiotics, pharmaceutical compositions containing the probiotics, and methods of using them to treat gastrointestinal diseases or disorders. In some aspects, the present disclosure provides such compositions comprising Anaerospis hadrus bacterial strains and their use in the treatment of intestinal diseases or disorders.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Application Serial No. 62 / 689,278, filed June 25, 2018, the entire contents of which are incorporated herein by reference. [0003] Cross Reference to Sequence Listing [0004] The contents of the electronically submitted text file are hereby incorporated by reference in their entirety: Copy of Sequence Listing filename SG301Dseqlist.txt (13684 bytes on disc) in computer readable format, created June 25, 2018. [0005] field of invention [0006] The present disclosure relates to novel and therapeutically effective compositions comprising microorganisms, in particular Anaerostipeshadrus. The microbial composition is particularly applicable to treating, improving and / or preventing gastrointestinal inflammatory diseases and / or epithelial barrier function disorders. [0007] Background of the invention [0008] Inflammatory bowel disease (IBD) is a heterogeneous disease...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A61P1/00A61P1/04A61P1/12
CPCC12Q1/689C12Q1/6883C12Q2600/106A61K35/74A61P1/00A61K35/742
Inventor S.卡瓦纳T.Z.德桑蒂斯M.J.克拉森F.J.瑞安
Owner SECOND GENOME