Compound lucid ganoderma composition for improving senile dementia and preparation method thereof

A technology for Alzheimer's disease and composition, which is applied in the field of compound Ganoderma lucidum composition and preparation for improving Alzheimer's disease, and can solve problems such as not having Alzheimer's disease

Inactive Publication Date: 2021-05-18
ZHONGKE HEALTH IND GRP JIANGSU PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern medicine shows that Ganoderma lucidum has the biological functions of anti-oxidation, anti-aging, lowering blood sugar, and lowering blood fat. The series of products developed according to Ganoderma lucidum cover the fields of medicine, health care and daily chemicals, among which medicine and health care products are mainly used to improve immunity. Strength and anti-aging are the main functions, and there is no health food for Alzheimer's disease

Method used

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  • Compound lucid ganoderma composition for improving senile dementia and preparation method thereof
  • Compound lucid ganoderma composition for improving senile dementia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] In parts by weight, the raw materials of the composition in this example include: 5 parts of Ganoderma lucidum extract, 3 parts of Ginkgo biloba extract, 7 parts of Cistanche, 6 parts of Gastrodia elata, 5 parts of Polygonatum, 4 parts of Jujube Seed, 6 parts of Salvia miltiorrhiza, 6 parts of Angelica sinensis share.

[0027] Its preparation steps are as follows:

[0028] S1. Take Cistanche deserticola, Gastrodia elata, Rhizoma Polygonatum, Jujube Seed, Salvia miltiorrhiza and Chinese angelica in parts by weight, mix and coarsely pulverize (that is, pulverize until the particle size of the material is 3-6cm) to obtain coarse pulverization; add hot water with 6 times the weight of the coarse pulverization , decoct in water for 1 hour, extract 3 times, and combine the extracts to form the water extract; the water extract is cooled to room temperature and concentrated to a density of 1.26g / cm 3 , add a 90% ethanol solution to make the alcohol content reach 60%, let stand...

Embodiment 2

[0032] In parts by weight, the raw materials of the composition in this example include: 4 parts of Ganoderma lucidum extract, 3 parts of Ginkgo biloba extract, 6 parts of Herba Cistanche, 6 parts of Gastrodia elata, 5 parts of Polygonatum, 7 parts of Jujube Seed, 6 parts of Salvia miltiorrhiza, 5 parts of Angelica sinensis share.

[0033] The preparation method is the same as in Example 1.

[0034] The compound Ganoderma lucidum composition obtained in Example 1 is further described by the rat water maze experiment below:

[0035] 1. Rat water maze test

[0036] 1), experimental animals

[0037] SD male rats, weighing 220±20g, were provided by the Animal Laboratory of China Pharmaceutical University. The feed was conventional pellet feed. The feeding conditions were: air-conditioned room, temperature 18-24°C, relative humidity 70%. The animals were adapted for two days at 22°C, 50% relative humidity and 12 hours of light-12 hours of darkness, and sensitive and timid rats w...

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Abstract

The invention provides a compound lucid ganoderma composition for improving senile dementia and a preparation method thereof, and relates to the field of traditional Chinese medicines. The compound lucid ganoderma composition is prepared from 5 parts of lucid ganoderma extract, 3 parts of ginkgo leaf extract, 7 parts of herba cistanche, 6 parts of rhizoma gastrodiae, 5 parts of rhizoma polygonati, 4 parts of semen ziziphi spinosae, 6 parts of radix salviae miltiorrhizae and 6 parts of radix angelicae sinensis. The lucid ganoderma composition adopts a pure natural formula, has no side effect, and can relieve and treat senile dementia; and the escape latency of the Morris water maze can be shortened, and the learning and memory functions of rats can be remarkably improved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, in particular to a compound ganoderma composition for improving senile dementia and a preparation method thereof. Background technique [0002] Alzheimer's disease is a chronic degenerative disease of the nervous system, mainly manifested as memory dysfunction. At present, there are no effective drugs and methods for the treatment of senile dementia. Commonly used cholinesterase inhibitors such as galantamine and ambenzium chloride are clinically used; pyrrolidone derivatives that improve brain tissue metabolism such as piracetam ( Naofukang) can alleviate some symptoms and slow down the progress of the disease, but the above-mentioned drugs have side effects such as nausea, sweating, and bradycardia. In traditional Chinese medicine, the causes of Alzheimer's disease are attributed to deficiency, blood stasis, and phlegm. It is characterized by deficiency in origin and exce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8988A61P25/28
CPCA61K36/074A61K36/16A61K36/232A61K36/537A61K36/64A61K36/725A61K36/8969A61K36/8988A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P25/28A61K2300/00
Inventor 施巍巍罗景周亚杰韩丰成
Owner ZHONGKE HEALTH IND GRP JIANGSU PHARM CO LTD
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