Traditional Chinese medicine compound extract for treating intestinal coccidiosis of rabbits and application thereof

An extract and compound technology, applied in the field of traditional Chinese medicine compositions, can solve the problems of immunosuppression and drug resistance, high levels of rabbit coccidiosis, and lack of targeted drugs, so as to repair intestinal mucosal damage and have broad research value. and application prospects, the effect of prevention and treatment of secondary infection

Active Publication Date: 2021-06-11
SICHUAN ANIMAL SCI ACAD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many kinds of drugs currently used to treat rabbit coccidiosis, the rabbit coccidiosis is still high, mainly because there is no commercial vaccine; and in production, people continue to add to the feed almost throughout the whole process of raising rabbits except for the pregnancy stage. Low-dose anticoccidial drugs, so not only is there no targeted selection of drugs, but also it is very easy to cause the emergence of drug-resistant coccidiostat strains due to long-term use of an anticoccidial drug, and there is a partial crossover between ionophore drugs resistance
In order to better control coccidiosis, drugs must be exchanged frequently, which also leads to greatly increased production costs
At the same time, the toxicity, residue, immunosuppression and drug resistance of chemical drugs seriously plague their application, seriously affecting and endangering human health

Method used

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  • Traditional Chinese medicine compound extract for treating intestinal coccidiosis of rabbits and application thereof
  • Traditional Chinese medicine compound extract for treating intestinal coccidiosis of rabbits and application thereof
  • Traditional Chinese medicine compound extract for treating intestinal coccidiosis of rabbits and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation of embodiment 1 Chinese medicine compound extract

[0035] According to 60 parts of hawthorn, 60 parts of Changshan, 60 parts of betel nut, 60 parts of licorice, 120 parts of scutellaria, 120 parts of berberine, and 120 parts of peony, add distilled water according to 5 times the total weight of the drug, and perform ultrasonic soaking for 1-1.5 hours. Start decocting, set the decocting temperature at 90-100°C, and decoct for 5-6 hours, filter to obtain the original drug filtrate, and repeat the above steps for the filter residue 3 times, and finally combine all the filtrates. The resulting filtrate was added with 95% ethanol in a ratio of 10:6 for alcohol precipitation treatment. After standing still for 0.5-1 hour, the supernatant was transferred to a rotary evaporator for concentration until the volume of the concentrated solution accounted for 1 / 9 of the volume of the filtrate. Set The concentration temperature is 60-70°C to obtain a concentrated sol...

Embodiment 2

[0037] 160 parts of Pulsatilla, 120 parts of Coptis chinensis, 60 parts of Changshan and betel nut each, 60 parts of malt, divine comedy, and Brucea javanica. The extraction method is the same as in Example 1.

Embodiment 3

[0039] 120 grams of coptis, 80 grams of woody fragrance, 60 grams each of betel nut, Atractylodes macrocephala, Changshan, and betel nut. The extraction method is the same as in Example 1.

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Abstract

The invention discloses a traditional Chinese medicine compound extract for treating rabbit intestinal coccidiosis and application thereof. The traditional Chinese medicine compound extract comprises the following raw material medicines in parts by weight: 40-80 parts of hawthorn, 40-80 parts of antifebrile dichroa, 40-80 parts of betel nuts, 40-80 parts of liquorice, 100-150 parts of scutellaria baicalensis, 100-150 parts of coptis chinensis and 100-150 parts of Chinese herbaceous peony. The traditional Chinese medicine compound extract disclosed by the invention can reduce oocyst discharge and effectively treat rabbit intestinal coccidiosis caused by Eimeria maxima, Eimeria media, Eimeria flavescens and Eimeria minalis, and has wide research value and application prospect clinically.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine compositions, in particular to a Chinese medicine compound extract for treating rabbit intestinal coccidiosis and its application. Background technique [0002] Rabbit coccidiosis is a common and serious infectious disease caused by a variety of single-celled organisms of the genus Eimeria, parasitic in the small intestine or bile duct epithelial cells of rabbits. At present, seven species of Eimeria have been found in my country that can parasitize the small intestine and bile duct of rabbits. These single-celled organisms belong to the class of protozoa and they are most commonly called oocysts. Oocysts, so-called non-spore-forming oocysts, are excreted by animals in their feces. They remain in the environment and form spores. These sporulated oocysts, if ingested, cause diarrhea and sometimes death of the animal. Rabbit coccidian oocysts can develop into infectious oocysts in 2 t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/889A61P33/02
CPCA61K36/734A61K36/185A61K36/889A61K36/484A61K36/539A61K36/718A61K36/71A61K36/65A61P33/02A61K2236/331A61K2300/00
Inventor 叶勇刚康润敏魏勇谢晶林毅于吉锋肖璐曹冶叶健强吴学婧李兴玉张先惠潘梦
Owner SICHUAN ANIMAL SCI ACAD
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