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Pro-ADM for prognosing the risk of medical condition requiring hospitalization in patients with symptoms of infectious disease

A technology for infectious diseases and patients, applied in the direction of scientific instruments, instruments, measuring devices, etc.

Pending Publication Date: 2021-06-29
BRAHMS GMBH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This puts unnecessary pressure on hospitals as the vast majority of these patients do not actually require admission

Method used

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  • Pro-ADM for prognosing the risk of medical condition requiring hospitalization in patients with symptoms of infectious disease
  • Pro-ADM for prognosing the risk of medical condition requiring hospitalization in patients with symptoms of infectious disease
  • Pro-ADM for prognosing the risk of medical condition requiring hospitalization in patients with symptoms of infectious disease

Examples

Experimental program
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example

[0232] The invention is further described by reference to the following non-limiting examples.

[0233] background:

[0234] 80% of sepsis cases start in the community before being hospitalized. The success of sepsis treatment depends on timing. Early diagnosis of sepsis in the community (e.g. in primary care centers) (e.g. by healthcare professionals (i.e. GPs) who first encounter patients with infectious disease symptoms) should be a priority for reducing morbidity and mortality from this disease.

[0235] The main research objectives described in the examples:

[0236] The goal is to find the best biomarkers to identify patients in the community (i.e. at GPs) with suspected (preferably respiratory) infection who need to be transferred to the hospital, i.e. the hospital's emergency department (ER) and who need to be referred to It is distinguished from those patients who were not transferred to the hospital.

[0237] The predictive power of biomarkers was compared wi...

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Abstract

The invention relates to a method for therapy guidance, stratification and / or control in a patient with symptoms of an infectious disease, comprising a prognosis of disease progression, the method comprising: providing a sample from the patient, and determining a level of proADM or fragment(s) thereof in the sample, wherein a low risk level of proADM level or fragment(s) thereof in the sample indicates that the patient is not at risk of a disease progression to a condition that requires hospitalization, wherein the low risk level is preferably equal or below 1.2 nmol / l + / - 20%, and / or wherein a high risk level of proADM level or fragment(s) thereof in the sample indicates that the patient is at risk of a disease progression to a condition that requires hospitalization, wherein the high risk level is preferably above 1.2 nmol / l + / - 20%. The invention further relates to a test kit for carrying out the method.

Description

[0001] illustrate [0002] The present invention relates to a method for the treatment guidance, stratification and / or management of a patient with symptoms of an infectious disease, said method comprising prognosis of disease progression, said method comprising: providing a sample from said patient , and determining the level of proADM or a fragment thereof in the sample, wherein a low risk level of the level of proADM or a fragment thereof in the sample indicates that the patient is not at risk of disease progression to a condition requiring hospitalization, wherein the low risk Levels are preferably equal to or lower than 1.2 nmol / l ± 20%, and / or wherein a high risk level of proADM levels or fragments thereof in said sample indicates that said patient is at risk of disease progression to a condition requiring hospitalization, wherein all Said high risk level is preferably higher than 1.2 nmol / l ± 20%. The invention further relates to a test kit for carrying out said method....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/74
CPCG01N33/6893G01N33/74
Inventor D·威尔逊J·F·贝尔梅霍马丁L·加西亚奥蒂兹C·赫雷洛罗德利圭兹
Owner BRAHMS GMBH