Dynamic organic gadolinium nanoparticle and application thereof

A nanoparticle, organic gadolinium technology, applied in nanomedicine, nanotechnology, nanotechnology and other directions to achieve the effect of easy modification

Active Publication Date: 2021-07-02
武汉中科极化医疗科技有限公司
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, gadolinium-containing nanoparticle system

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Dynamic organic gadolinium nanoparticle and application thereof
  • Dynamic organic gadolinium nanoparticle and application thereof
  • Dynamic organic gadolinium nanoparticle and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028]1. Synthesis of gadolinium precursors:

[0029] According to the literature (Liang.G L.et a1.Controlled Self-Assembling of Gadolinium Nanoparticles as Smart Molecular Magnetic Resonance Imaging ContrastAgents.Angew.Chem.Int.Ed., 50,6283-6286, (2011)) disclosed method to synthesize;

[0030] 2. Synthesis of gadolinium intermediates:

[0031] 2.1. Prepare Gd-precursor aqueous solution and 4mM tris(2-carboxyethyl)phosphine (TCEP) aqueous solution with a concentration of 100 μM respectively;

[0032] 2.2. Take 1 mL of 100 μM Gd-precursor aqueous solution, add 1 μL of 4 mM TCEP aqueous solution to it, and stir at room temperature to obtain a gadolinium intermediate, which is designated as Gd-intermediate;

[0033] 3. Preparation of organic gadolinium nanoparticles:

[0034] Prepare Na with a concentration of 0.1M 2 CO 3 aqueous solution, the gadolinium intermediate is replaced with Na 2 CO 3 Adjust the pH value of the aqueous solution to 6.0, and stir at room temperatur...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Longitudinal relaxation rateaaaaaaaaaa
Transverse relaxation rateaaaaaaaaaa
Login to view more

Abstract

The invention discloses a dynamic organic gadolinium nanoparticle and application thereof. The nanoparticle is prepared by the following method: 1, respectively preparing a 100 [mu] M gadolinium precursor aqueous solution and a 4 mM tris (2-carboxyethyl) phosphine aqueous solution; 2, mixing the gadolinium precursor aqueous solution and the tris (2-carboxyethyl) phosphine aqueous solution according to the molar ratio of the gadolinium precursor to the tris (2-carboxyethyl) phosphine of 25: 1, and stirring at room temperature to obtain a gadolinium intermediate; and 3, adjusting the pH value of the gadolinium intermediate to 6.0 by using a Na2CO3 aqueous solution, and stirring at room temperature to obtain the dynamic organic gadolinium nanoparticle. The particle size of the nanoparticle can be dynamically changed in different stages of self-assembly, the nano-particles can be used as a T1 contrast agent and a T2 contrast agent in different stages of self-assembly, the same contrast agent can realize positive enhancement and negative enhancement effects of MRI signals, and the detection accuracy can be effectively improved.

Description

technical field [0001] The invention relates to the technical field of magnetic resonance imaging, in particular to a dynamic organic gadolinium nanoparticle and an application thereof. Background technique [0002] Magnetic resonance imaging (MRI), as a non-invasive and radioactive imaging technique, has long been used as one of the important imaging tools for medical diagnosis. Compared with other medical imaging techniques, such as computed tomography (CT), positron emission tomography (PET) and single photon emission computed tomography (SPECT), MRI has many advantages, such as non-destructive and non-invasive to the examination object, Three-dimensional image information with high spatial resolution and soft tissue contrast can be acquired. However, MRI has the disadvantage of relatively low sensitivity in medical diagnosis. At present, the sensitivity of MRI is mainly improved by enhancing the imaging contrast. The application of MRI contrast agents can effectively e...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K49/10A61K49/00A61K49/18B82Y5/00B82Y15/00
CPCA61K49/108A61K49/0002A61K49/1833B82Y5/00B82Y15/00
Inventor 陈世桢孙献平周欣
Owner 武汉中科极化医疗科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap