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Application of regulatory T cells in drug preparation or cell therapy for autism treatment

A cell therapy, autism technology, applied in the field of medicine, can solve problems such as no autism

Active Publication Date: 2021-07-06
SHANGHAI MENTAL HEALTH CENT (SHANGHAI PSYCHOLOGICAL COUNSELLING TRAINING CENT)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] So far, there is no report on the use of regulatory T cells to treat autism

Method used

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  • Application of regulatory T cells in drug preparation or cell therapy for autism treatment
  • Application of regulatory T cells in drug preparation or cell therapy for autism treatment
  • Application of regulatory T cells in drug preparation or cell therapy for autism treatment

Examples

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Embodiment Construction

[0024] The solutions of the present invention will be explained below in conjunction with examples. Those skilled in the art will understand that the following examples are only for illustrating the present invention and should not be considered as limiting the scope of the present invention. If no specific technique or condition is indicated in the examples, it shall be carried out according to the technique or condition described in the literature in this field or according to the product specification. The reagents or instruments used were not indicated by the manufacturer, and they were all commercially available conventional products. The experimental methods used are conventional methods unless otherwise specified. This example uses autism model mice to provide an embodiment of using the above-mentioned expanded and cultured regulatory T cells to effectively alleviate the symptoms of autism. The specific operation steps are as follows:

[0025] (1) Blood was collected ...

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Abstract

The invention relates to application of regulatory T cells in cell therapy or drug preparation for autism treatment. Through targeted research on autism pathogenesis and the regulatory T cells, it is found that core symptoms of autism model mice can be effectively eliminated or relieved by infusing the regulatory T cells into immunoabnormal type autism model mice, and the problem that autism can not be treated at present is expected to be solved in the future.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of regulatory T cells in autism cell therapy or in the preparation of drugs for treating autism. Background technique [0002] The immune system is an important system for the body to carry out immune response and immune function. It is composed of immune organs, immune cells and immune molecules. The immune system has the functions of identifying and eliminating antigenic foreign bodies, coordinating with other systems of the body, and jointly maintaining the stability and physiological balance of the body's internal environment. [0003] In the immune cell system, regulatory T cells only account for 1-3% of human peripheral immune cells, but they are very few cell types that can inhibit immune activation and maintain immune homeostasis. [0004] The regulatory T cells described in the present invention include different cell subsets, according to the common d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/17A61P25/00A61P25/22C12N5/0783
CPCA61K35/17A61P25/22A61P25/00C12N5/0637C12N2509/00C12N2501/515C12N2501/51
Inventor 周子凯张小云季旻珺徐志鹏
Owner SHANGHAI MENTAL HEALTH CENT (SHANGHAI PSYCHOLOGICAL COUNSELLING TRAINING CENT)