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Traditional Chinese medicine composition for treating type II diabetes mellitus and preparation method of traditional Chinese medicine composition

A composition and technology for diabetes, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of uneven quality of raspberries, low yield of trichosanthin and high price

Active Publication Date: 2021-07-23
LUNAN HOPE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention is aimed at the limited clinical use of Shenqi Jiangtang prescription, and the low yield and high price of trichosanthemi in the prescription, the uneven quality of raspberries and low pass rate Problem, based on a scientific and prudent attitude, the present invention provides a traditional Chinese medicine composition for treating type Ⅱ diabetes and its preparation method on the basis of the patent CN1245198C, so that it has better antidiabetic function and clinical curative effect of Shenqi , and can replace trichosanthes and raspberry with other medicinal flavors, so as to avoid possible problems in the supply and quality of raw materials

Method used

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  • Traditional Chinese medicine composition for treating type II diabetes mellitus and preparation method of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for treating type II diabetes mellitus and preparation method of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for treating type II diabetes mellitus and preparation method of traditional Chinese medicine composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0136] The preparation of embodiment 1 granule

[0137]

[0138] A. Chinese yam, Poria cocos, Atractylodes macrocephala, Anemarrhena anemarrhena, crushed into fine powder Ⅰ, set aside;

[0139] B. Dipping Ophiopogon japonicus with 6 times the amount of warm water for two times, each time for 2 hours, filtering, combining the filtrates, concentrating under reduced pressure to obtain extract I with a relative density of 1.40, and set aside;

[0140] C. Fructus Schisandra is percolated with 10 times the amount of 50% ethanol, filtered, and the ethanol is recovered under reduced pressure, concentrated into extract II with a relative density of 1.40 for later use;

[0141] D. Cornus officinalis, reed root, medlar, astragalus, rehmannia glutinosa, Alisma, kudzu root Qiwei, decoct twice with 10 times the amount of water, 2 hours each time, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to a thick consistency with a relative density of 1.20 paste...

Embodiment 2

[0143] The preparation of embodiment 2 pills

[0144]

[0145] A. Chinese yam, Poria cocos, Atractylodes macrocephala, Anemarrhena anemarrhena, crushed into fine powder Ⅰ, set aside;

[0146] B. Immerse Ophiopogon japonicus in 5 times warm water for 3 times, each time for 0.5h, filter, combine the filtrate, concentrate under reduced pressure into extract I with a relative density of 1.30, and set aside;

[0147] C. Schisandra chinensis is percolated with 8 times the amount of 40% ethanol, filtered, and the ethanol is recovered under reduced pressure, concentrated into extract II with a relative density of 1.30 for later use;

[0148] D. Cornus officinalis, reed root, medlar, astragalus, rehmannia root, Alisma, pueraria seven flavors, decoct twice with 10 times the amount of water, 1 hour each time, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to a relative density of 1.25. paste, let it cool, add 95% ethanol to make the alcohol content ...

Embodiment 3

[0150] The preparation of embodiment 3 tablet

[0151]

[0152] A. Chinese yam, Poria cocos, Atractylodes macrocephala, Anemarrhena anemarrhena, crushed into fine powder Ⅰ, set aside;

[0153] B. Soak Ophiopogon japonicus in 10 times the amount of warm water for 3 hours, filter, combine the filtrates, concentrate under reduced pressure to obtain extract I with a relative density of 1.35, and set aside;

[0154] C. Fructus Schisandra was percolated with 12 times the amount of 70% ethanol, filtered, and the ethanol was recovered under reduced pressure, concentrated into extract II with a relative density of 1.35 for later use;

[0155] D. Cornus officinalis, reed root, medlar, astragalus, rehmannia root, Alisma, and kudzu root Qiwei, decocted with 9 times the amount of water for 3 times, each time for 0.5h, filtered, combined the filtrate, and concentrated the filtrate under reduced pressure to a relative density of 1.15 Let the extract cool, add 95% ethanol to make the alco...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition for treating type II diabetes mellitus and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from ginsenoside, rhizoma atractylodis macrocephalae, radix rehmanniae, radix astragali, rhizoma dioscoreae, rhizoma phragmitis, radix ophiopogonis, fructus schisandrae, fructus lycii, rhizoma alismatis, poria cocos, radix puerariae, rhizoma anemarrhenae and fructus corni. The traditional Chinese medicine composition has the effects of tonifying qi and yin, tonifying the spleen and kidney, clearing heat for promoting salivation, and promoting blood circulation to remove blood stasis. Pharmacodynamic researches show that after the traditional Chinese medicine composition intervenes in a type II diabetic db / db mouse, the basic blood glucose value of the mouse can be remarkably reduced, the phenomena of polydipsia and polyphagia are improved, the glucose tolerance is improved, the serum insulin level, the glycosylated hemoglobin level and the total cholesterol level are reduced, and the curative effect is not remarkably different from that of an independent clinical medicine. Therefore, the traditional Chinese medicine composition can be used as the clinical independent medicine and has value of treating the type II diabetes mellitus.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine and relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to a traditional Chinese medicine composition for preventing or treating type II diabetes and a preparation method thereof. Background technique [0002] Diabetes mellitus is a syndrome of complex etiology. It is an absolute or relative deficiency of insulin, or a series of metabolic disorder syndromes characterized by hyperglycemia, such as sugar, fat, protein, water and electrolytes caused by insulin resistance. The long-term existence of hyperglycemia characteristics will lead to chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves. In recent years, with the rapid improvement of my country's economic and social development level, people's diet structure has changed, the pace of life has accelerated, the aging ...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P3/10
CPCA61K36/258A61K36/284A61K36/804A61K36/481A61K36/8945A61K36/899A61K36/8968A61K36/79A61K36/57A61K36/815A61K36/884A61K36/076A61K36/488A61K36/8964A61K36/40A61K9/0053A61P3/10A61K2236/331A61K2236/333A61K2300/00Y02A50/30
Inventor 张贵民冯倩赵昆
Owner LUNAN HOPE PHARM CO LTD
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