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Method of detecting cancer and/or tuberculosis

A cancer, subject technology, applied in the field of cancer and/or tuberculosis detection, which can solve problems such as difficult treatment of lung cancer

Pending Publication Date: 2021-07-23
NAT UNIV OF SINGAPORE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lung cancer remains difficult to treat despite extensive research into treatments for the disease

Method used

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  • Method of detecting cancer and/or tuberculosis
  • Method of detecting cancer and/or tuberculosis
  • Method of detecting cancer and/or tuberculosis

Examples

Experimental program
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Effect test

example 1

[0185] figure 1 Total ion chromatograms (TICs) for each representative set of samples are shown, with each peak labeled with the compound name. Using the kruskal-wallis test and VIP calculation in the OPLS-DA model, a total of 13 compounds were found to be statistically different. figure 2 a) is the OPLS-DA score map of VOCs in the discovery set. In this graph, each breath sample is represented by a dot. It showed a clear distinction between lung cancer subjects and control subjects and between lung cancer patients and tuberculosis patients. The relative concentrations of each VOC were linearly normalized to a range of -1 to 1 and plotted at figure 2 b) as shown in the color-coded diagram. Receiver operating characteristic (ROC) analysis was performed on discovery set samples using 13 compounds. The area under the curve (AUC) for each compound is listed in Table 4. Among these 13 compounds, 8 compounds with AUC values ​​greater than 0.75 (hexanal, heptanal, octanal, be...

example 2

[0187] In this study, seven aldehydes (including hexanal, heptanal, octanal, decanal, dodecanal, benzaldehyde, phenylacetaldehyde) were found in the breath of lung cancer patients compared to non-lung cancer controls content increased. This may be due to elevated levels of alcohol dehydrogenase (ADH) in cancer tissue. It is believed that ADH is overactivated in cancer cells, which means that cancer cells have a higher ability to oxidize alcohols to aldehydes. Alcohol is an alkane product produced by cytochrome p450, which in turn is a lipid peroxidation product, a process that is also upregulated in cancer cells. The breath samples of lung cancer patients have higher levels of hexanal and heptanal. These aldehydes are likely products of cancerous pathological processes. Benzaldehyde was found to be increased in lung cancer cell cultures. Higher levels of the alkane undecane were also found in this study. Undecane is a by-product of lipid peroxidation caused by reactive ox...

example 3

[0194] in conclusion

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Abstract

The invention relates to a method of detecting the presence of cancer in a subject based on a panel of biomarkers in exhaled breath. The disclosure also teaches a method of detecting tuberculosis and to distinguish the detection of tuberculosis from cancer or to distinguish the detection of cancer from tuberculosis.

Description

technical field [0001] The present disclosure relates to the field of cancer and / or tuberculosis detection. In particular, the present disclosure teaches a method of detecting the presence of cancer in a subject based on a panel of biomarkers in exhaled breath. The present disclosure also teaches a method of detecting tuberculosis and distinguishing the detection of tuberculosis from the detection of cancer. Background technique [0002] Lung cancer is the leading cause of cancer-related death worldwide, claiming 1.6 million deaths annually. Most lung cancer cases are diagnosed at an advanced stage where treatment is no longer curable. More than two-thirds of symptomatic patients present with lymph node or distant metastases. Early detection of lung cancer is difficult because clinical symptoms cannot be observed until the disease reaches an advanced stage. Currently, early detection of lung cancer is currently performed with the aid of chest computed tomography, analysi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/497
CPCA61B5/082G01N33/57423G01N2033/4975G01N2333/35G01N33/5695G01N33/98G01N33/497G01N2560/00
Inventor 贾祝楠文基·瑟鲁马莱·文卡特桑李萍
Owner NAT UNIV OF SINGAPORE
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