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Apparatus and process for coating tablets

A process method and tablet technology, applied in the field of tablet coating, can solve the problems of tablet abrasion, tablet long-lasting mechanical stress, low production force and the like

Inactive Publication Date: 2003-12-24
艾罗美蒂克－菲尔德股份公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0022] It has been proven that the presence of partition walls in the tubes used for tablet coating, such as in the examples of the above-mentioned U.S. Patent 3,241,520 and WO 95 / 20432, not only involves the problems of abrasion of the tablets thereon and the formation of sticky deposits, but also due to the use of partition walls The structure, which maintains a thick layer of the object to be coated on the outside of the partition, requires a long dwell time of the product, resulting in low forces and long continuous mechanical stress on the tablet

Method used

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  • Apparatus and process for coating tablets
  • Apparatus and process for coating tablets
  • Apparatus and process for coating tablets

Examples

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example

[0074] The coating operation was carried out in the apparatus shown in FIG. 1 .

[0075] The dimensions of the device are such that the horizontal diameter of the inclined surface 6 is 40 mm.

[0076] The tablets to be coated are round and have the following dimensions:

[0077] 7.0mm in diameter

[0078] Height 4.5mm

[0079] Surface area 6.6×10 -5 m 2

[0080] Each tablet weighed 0.164 grams, while the number of tablets in the batch was 200, corresponding to a total weight of 32 grams.

[0081]Coating solution is Opadry of 20% by weight  YS-1-7003 aqueous solution, which is a coating based on hydroxypropyl methyl cellulose.

[0082] surroundings:

[0083] Temperature 19°C

[0084] 64% relative humidity

[0085] Gas inlet temperature input to the pressure chamber 108%

[0086] Process gas flow rate input to pressure chamber 9 0.00684 m 3 / Second

[0087] Velocity of process gas through pipeline 7 and outlet 14 128 m / s

[0088] Spray pressure 2.5 bar...

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Abstract

A non-fluidized bed apparatus for coating tablets has a base plate of which a portion of the upper surface is inclined towards an upward directed two-fluid or three-fluid nozzle. Ducts through the base plate around the nozzle produce jets of process gas in a direction intersecting an imaginary centre line of the spray produced by the nozzle. Atomizing gas from the nozzle is muffled shortly after it has left the nozzle to decrease the upward scattering effect of said gas on the tablets being coated. No partition is used for separating upward and downward flow of tablets during the coating process. In the coating process the amount of atomizing gas supplied to the nozzle is limited to reduce the tablet scattering effect of said gas.

Description

field of invention [0001] The present invention relates to the coating of tablets. Wherein the term "tablet" is used in a broad sense including not only actual tablets in the pharmaceutical industry but also pills and sachets and in the fertilizer and agrochemical industries also pills and granules. [0002] Thus, the invention is not limited to any particular industrial scope, but is applicable in the coating of any type of object having an average particle size in the range from about 2 mm to 50 mm, especially from 3 mm to 25 mm. [0003] Coating operations are also important in some other industrial ranges than the above-mentioned industries, such as in the purification industry, the catering and food industry, and the catalyst manufacturing industry. [0004] Coatings can be applied for several purposes, such as to obtain a desired color or other visual improvement, to obtain a sustained or otherwise controlled release of the active ingredient, to protect the tablet from ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61J3/06B01J2/00B01J2/16B05B7/08B05C5/02B05C9/04B05D1/02B05D7/00
CPCB01J2/006B05B13/025Y10S118/05
Inventor K·T·瓦尔特M·A·奈德林格
Owner 艾罗美蒂克－菲尔德股份公司