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Application of trigonal total phenol extract in preparation of medicine for treating disseminated intravascular coagulation

An extract and dispersive technology, which is applied in the application field of the trigonal total phenol extract in the preparation of drugs for the treatment of disseminated intravascular coagulation, can solve the problems of insufficient research and achieve the purpose of increasing the mitochondrial membrane potential and improving cell survival rate, the effect of reducing LDH levels

Active Publication Date: 2022-02-25
SHANDONG ACAD OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, for drugs that require precision medicine, the existing research is not deep enough

Method used

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  • Application of trigonal total phenol extract in preparation of medicine for treating disseminated intravascular coagulation
  • Application of trigonal total phenol extract in preparation of medicine for treating disseminated intravascular coagulation
  • Application of trigonal total phenol extract in preparation of medicine for treating disseminated intravascular coagulation

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Embodiment 1

[0025] (1) Preparation of TPS-SL from trigonal total phenolic extract: take 1000g trigonal sample, crush it and pass it through a No. 4 sieve, soak in 10 times the amount of 80% ethanol for 30min, heat and reflux for 60min, repeat twice, combine the filtrate, and spin in vacuum The evaporator (60°C) recovers ethanol and concentrates to extract. Take an appropriate amount of extract and absorb it with polyamide resin (80-100 mesh), the mass ratio of extract to polyamide resin is 1:3, and elute with water and 80% ethanol in sequence, and the elution volume is 3 times the column volume (BV) , the elution flow rate was controlled at 0.6mL·min -1 , collected 80% ethanol eluate, concentrated under reduced pressure, and dried in a vacuum oven to obtain 135 g of dry extract. The prepared TPS-SL samples were stored in a -20°C refrigerator.

[0026] The components of TPS-SL were analyzed by HPLC-MS. 1g∙ml -1 The ingredients and content contained in the crude drug amount are: p-Hydro...

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Abstract

The invention belongs to the technical field of new uses of medicines, and in particular relates to the application of trigonium total phenol extracts in the preparation of medicines for treating disseminated intravascular coagulation. The preparation method of the trigonal total phenol extract is as follows: take an appropriate amount of triangular medicinal materials, pulverize, reflux with ethanol, combine the filtrates, and concentrate under vacuum to an extract; the extract is adsorbed by polyamide resin, and eluted with water and ethanol in sequence, Concentrate under reduced pressure and dry in vacuo to obtain the total phenolic extract. The TPS-SL extract of trigonal total phenols described in the present invention is more accurately targeted at specific diseases in the treatment of disseminated intravascular coagulation, so that patients can more clearly and quickly select trigonal total phenols after the cause of the disease is detected. The extract preparation is used for intervention treatment, laying the experimental foundation for the development of a new drug for the prevention and treatment of sepsis complicated by disseminated intravascular coagulation.

Description

technical field [0001] The invention belongs to the technical field of new uses of medicines, and in particular relates to the application of trigonium total phenol extracts in the preparation of medicines for treating disseminated intravascular coagulation. Background technique [0002] Disseminated intravascular coagulation (DIC) is a common clinical coagulation disorder, based on some diseases, the microvascular system is destroyed by some pathogenic factors, thereby activating the coagulation function in the blood, leading to microvascular thrombosis , causing the disease. Its etiology includes bacterial and fungal infections, malignant tumors, obstetric diseases, drug or food poisoning, etc. Sepsis is a systemic inflammatory response syndrome caused by infection. Coagulation dysfunction is closely related to sepsis. Coagulation disorder and inflammatory response promote and influence each other, and eventually develop multiple organ failure and death. DIC occurs in 30...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/902A61P7/02A61P29/00A61K125/00
CPCA61K36/902A61P7/02A61P29/00A61K2236/333A61K2236/39A61K2236/51A61K2236/55
Inventor 徐男时海燕王平
Owner SHANDONG ACAD OF CHINESE MEDICINE
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