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Medicine for preventing and treating cardiovascular and cerebrovascular diseases

A technology for cardiovascular and cerebrovascular diseases and drugs, applied in the direction of cardiovascular system diseases, blood diseases, drug combinations, etc., can solve problems such as unsatisfactory treatment effects of cannabidiol, reduce cerebral edema and cerebral infarction volume, and protect cardiovascular and cerebrovascular and tissues, reducing the percentage of brain necrosis

Inactive Publication Date: 2017-02-15
云南瑞酚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But cannabidiol (CBD) alone doesn't work as well

Method used

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  • Medicine for preventing and treating cardiovascular and cerebrovascular diseases
  • Medicine for preventing and treating cardiovascular and cerebrovascular diseases
  • Medicine for preventing and treating cardiovascular and cerebrovascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The flowers, leaves, hemp bran and hemp seeds of "Yunma No. 1", an industrial hemp variety grown in Yunnan, are used as raw materials. Take mature industrial hemp hemp seeds, dry, remove impurities, and crush them for later use; use ethanol to extract the crushed hemp seeds (at 60-85°C, heat and extract twice, each time for 1-3 hours ), the ethanol concentration is 95% to 100% (V / V), and the ratio of solid to liquid is 1:5 to 1:20; the extract is filtered out and concentrated under reduced pressure to obtain the industrial hemp hemp seed extract.

[0031]Take the mixture of industrial hemp flowers, leaves and hemp bran in a mass ratio of 1:3:2, dry, remove impurities, and pulverize to 10-60 mesh; supercritical carbon dioxide extraction: put the above-mentioned pulverized industrial hemp raw materials into supercritical In the carbon dioxide extraction device, the extraction temperature is controlled at 40-50°C, the extraction time is 30-90min, the extraction pressure is...

Embodiment 2

[0034] Repeat Example 1, with the following differences: when extracting industrial hemp hemp seeds with ethanol, extract at room temperature, and extract 2 times for each batch of materials, each for 7 to 10 days. A 1:1:1 mass ratio mixture of flowers, leaves, and hemp bran of industrial hemp is used as a raw material for extracting hemp cannabinoids.

[0035] Get 0.3 part of industrial hemp hemp seed extract, 99.7 parts of industrial hemp cannabinoid, mix well, obtain medicine A of the present invention.

Embodiment 3

[0037] Repeat Example 1, the following difference is arranged: when extracting industrial hemp hemp seed with ethanol, adopt ultrasonic assisted extraction, ultrasonic frequency 30~60kHz, power 100~1000W, extraction time 30~60min, leaching temperature 25~ 50°C. A 3:2:1 mass ratio mixture of flowers, leaves, and hemp bran of industrial hemp is used as the raw material for extracting hemp cannabinoids.

[0038] Get 99.7 parts of industrial hemp hemp seed extract, 0.3 part of industrial hemp cannabinoid, mix well, obtain medicine C of the present invention.

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Abstract

The invention discloses a medicine for preventing and treating cardiovascular and cerebrovascular diseases. The medicine is prepared by uniformly mixing 0.3-99.7 parts of an industrial hemp fructus cannabis extract and 99.7-0.3 parts of industrial hemp cannaboid. The pharmaceutical composition (the medicine) has functions of improving the activity of such anti-free radical enzymes as SOD, GSH-PX and the like, scavenging free radicals, protecting heart and cerebral vessels and tissues and preventing and treating the occurrence and development of the cardiovascular and cerebrovascular diseases. The prepared medicine is used for preventing and treating such cardiovascular and cerebrovascular diseases as cerebral ischemia, myocardial ischemia, neuron injury caused by hypoxia-reoxygenation, cerebral infarction (stroke), cerebral thrombosis, cerebral hemorrhage, coronary disease, myocardial infarction and the like. The medicine has a good application prospect in the aspect of preventing and treating the cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention belongs to the field of drugs for treating cardiovascular and cerebrovascular diseases, in particular to a pharmaceutical composition for preventing and treating cardiovascular and cerebrovascular diseases prepared from industrial hemp as a main raw material. Background technique [0002] The cultivation of hemp has a long history. In ancient times, hemp was mainly used to make and process ropes, fishing nets, clothing and paper-making raw materials, as well as oil and food. With the development and progress of society, people found that a toxic ingredient (tetrahydrocannabinol) in marijuana can make people addicted to hallucinations. Many countries in Europe and the United States have banned the cultivation of marijuana for a long time. Due to the high economic value of cannabis, by the 1980s, some European countries had researched and bred low-toxic cannabis varieties and promoted their cultivation. In 1990, the European Community took...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60A61P9/00A61P9/10A61P7/02
CPCA61K36/60A61K2236/333A61K2236/37A61K2300/00
Inventor 陈天睿胡瀞月
Owner 云南瑞酚生物科技有限公司
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