Amino acid compounds and methods of use

A compound, aminopyridine technology, applied in the field of therapeutic agents, can solve problems such as few treatment options
CN113195053APending Publication Date: 2021-07-30PLIANT THERAPEUTICS INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
PLIANT THERAPEUTICS INC
Publication Date
2021-07-30

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Abstract

The invention relates to compounds of formula (I), or a salt thereof, wherein R1, G, L1L2, L3, and Y are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are inhibitors of one, or both of, [alpha]V[beta]1 integrin and [alpha]V[beta]6 integrin that are useful for treating fibrosis such as in nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IFF) and nonspecific interstitial pneumonia (NSTP).
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Description

[0001] Cross References to Related Applications

[0002] This application claims the benefit of priority to U.S. Provisional Patent Application Serial No. 62 / 742,901, filed October 8, 2018, the entire contents of which are incorporated herein by reference. technical field

[0003] The present disclosure generally relates to therapeutic agents useful as inhibitors of αvβ6 integrins. The therapeutic agents are useful in the treatment or prevention of fibrosis, such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP). Background technique

[0004] Fibrosis, a pathological feature of many diseases, results from a malfunction in the body's natural ability to repair damaged tissue. If left untreated, fibrosis can lead to scarring of vital organs, causing irreparable damage and eventual organ failure.

[0005] Patients with nonalcoholic fatty liver disease (NAFLD) may progress from pure steatosis to nonalcoholic steatohepatitis (NASH) with subseq...

Claims

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