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Preparation method of gastrodia elata Toufengling tablets

A technology of Gastrodia elata and head wind, applied in the field of pharmaceutical preparations, can solve the problems of affecting the stability of pharmaceutical tablets, reducing tablet disintegration efficiency, and too tight tablet structure, so as to reduce bioavailability, accelerate dissolution, and achieve good disintegration. The effect of solution speed

Pending Publication Date: 2021-08-03
HAINAN HAILI PHARMACEUTICAL CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The Chinese patent application with the application number CN03118521.5 discloses a preparation method of Tianmatou Fengling Tablets. Although the cyclodextrin in it can promote the dissolution of the drug to a certain extent, it needs a variety of auxiliary materials, and in the production process A large number of auxiliary materials will also make the tablet structure too tight during the tablet compression process, thereby affecting the disintegration of the tablet. At the same time, the tablet described in this application is a film-coated tablet, and the disintegration efficiency of the tablet will also be affected by the According to the excipient ingredients described in the application, without coating, it is very easy to hydrolyze, thus affecting the stability of pharmaceutical tablets

Method used

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  • Preparation method of gastrodia elata Toufengling tablets
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  • Preparation method of gastrodia elata Toufengling tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1 A kind of preparation method of Tianmatou Fengling tablet A1

[0017] The present embodiment provides a kind of preparation method of Tianmatou Fengling tablet A1, and its preparation method comprises the following steps:

[0018] 1) Weigh 50g Uncaria, 215g Angelica, 50g Chuanxiong, 150g Dihuang, 50g Scrophulariaceae, 43g Eucommia, 215g Mistletoe, 50g Achyranthes bidentata and 50g Wild Chrysanthemum, add these nine herbs to 9.23L water and decoct three times, each After 2 hours, combine the decoction, filter, concentrate the filtrate to a thick paste with a relative density of 1.39 (50°C), then add 50g of gastrodia elata crushed into fine powder, mix evenly, dry, and crush through an 80-mesh sieve to obtain 800g of Gastrodia elata head Fengling dry cream powder;

[0019] 2) Weigh 800g Tianma head Fengling dry cream powder, 100g calcium hydrogen phosphate, 100g microcrystalline cellulose and 250g sodium carboxymethyl starch, add them to a granulator with a ...

Embodiment 2～6

[0023] The preparation method of embodiment 2~6 Tianmatou Fengling tablets A2~A6

[0024] The preparation methods of Tianmatou Fengling Tablets A2-A6 provided in Examples 2-6 are basically the same as those provided in Example 1, the only difference being that some process parameters are different, and the specific process parameters are shown in Table 1 .

[0025] Table 1: The preparation process parameters of Tianmatou Fengling Tablets A2~A6

[0026]

[0027]

[0028] Other steps are all the same as in Example 1.

experiment example 1

[0029] Experimental Example 1 Comparative Test of Disintegration Speed ​​of Tianmatou Fengling Tablets

[0030] In order to further illustrate the preparation method of Tianmatou Fengling Tablets provided by the present invention, this experimental example selects the preparation method in the Chinese patent application whose application number is 03118521.5 to prepare Tianmatou Fengling Tablets, as comparison group 1 and purchased Gastrodia Toufeng Ling tablets (Renhe Pharmaceutical, 0.38*9s), as the comparison group 2.

[0031] The Tianmatou Fengling Tablets A1-A6 prepared in Examples 1-6 provided in the present invention are respectively used as test groups 1-6.

[0032] Take out 24 Tianmatou Fengling Tablets from the comparison groups 1 and 2 and the test groups 1 to 6 respectively, put them into the disintegration apparatus, and carry out the test four times. Each time, 6 tablets are selected from each group for the test. The liquid environment used is water, respectively...

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Abstract

The invention belongs to the field of pharmaceutical preparations, and discloses a preparation method of gastrodia elata Toufengling tablets. The preparation method comprises the steps: mixing gastrodia elata Toufengling dry paste powder with calcium hydrophosphate, microcrystalline cellulose, sodium carboxymethyl starch and other auxiliary materials, granulating, drying, granulating and tabletting to obtain the gastrodia elata Toufengling tablets. The gastrodia elata Toufengling tablets prepared by the preparation method provided by the invention have a relatively high disintegration rate, so that the dissolution of effective components of the medicine is promoted. The preparation method is suitable for preparation of tablet medicines, and is particularly suitable for preparation of the gastrodia elata Toufengling tablets.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a preparation method of traditional Chinese medicine preparations, in particular to a preparation method of Tianmatou Fengling Tablets. Background technique [0002] Tianmatou Fengling Tablets are prescription medicines. The main ingredients include Gastrodia elata, Achyranthes bidentata, Scrophulariaceae, Rehmannia glutinosa, Angelica sinensis, Eucommia ulmoides, Chuanxiong, mistletoe, wild chrysanthemum, and Uncaria. It is mainly used to treat intractable headaches, long-term numbness in hands and feet, and chronic soreness in the waist and legs. [0003] The Chinese patent application with the application number CN03118521.5 discloses a preparation method of Tianmatou Fengling Tablets. Although the cyclodextrin in it can promote the dissolution of the drug to a certain extent, it needs a variety of auxiliary materials, and in the production process A large number of a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K36/8988A61K47/02A61K47/36A61K47/38A61P25/00A61P29/00
CPCA61K9/2059A61K9/2054A61K9/2009A61K36/8988A61K36/74A61K36/232A61K36/236A61K36/804A61K36/808A61K36/46A61K36/185A61K36/21A61K36/287A61P25/00A61P29/00A61K2300/00
Inventor 许丹青余国新耿亮朱亚东
Owner HAINAN HAILI PHARMACEUTICAL CO LTD
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