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A kind of Ganmao Qingre Capsule and its preparation method

A cold-clearing and capsule-based technology, applied in microcapsules, capsule delivery, antipyretics, etc., can solve problems such as hygroscopicity and fluidity to be improved, and achieve the goal of improving bioavailability, reducing hygroscopicity, and increasing disintegration rate Effect

Active Publication Date: 2021-01-26
GUANGDONG YILI LUODING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The capsule has a remarkable curative effect, but the hygroscopicity and fluidity of the capsule need to be improved

Method used

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  • A kind of Ganmao Qingre Capsule and its preparation method
  • A kind of Ganmao Qingre Capsule and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1 A kind of Ganmao Qingre Capsule

[0034] The Ganmao Qingre Capsule consists of pellets, a coating layer and a capsule shell, wherein

[0035] Described pellet is made up of following component and parts by weight thereof:

[0036] 40 parts of nepeta, 10 parts of mint, 20 parts of windproof, 10 parts of perilla leaves, 20 parts of kudzu root, 10 parts of bellflower, 10 parts of angelica dahurica, 40 parts of Kudiding, 30 parts of reed root, 20 parts of Bupleurum, bitter almond 15 parts, 1 part of chitosan-g-lactose, 1 part of β-cyclodextrin, 0.5 parts of starch, 1 part of hydroxypropyl cellulose, 85 parts of water and 5 parts of ethanol solution with a volume fraction of 85%;

[0037] The coating layer consists of the following components and parts by weight thereof:

[0038] 10 parts of hypromellose, 1 part of glyceryl triacetate, 1 part of magnesium stearate and 50 parts of ethanol solution with a volume fraction of 85%.

[0039] The preparation method ...

Embodiment 2

[0050] Embodiment 2 A kind of Ganmao Qingre Capsule

[0051] The Ganmao Qingre Capsule consists of pellets, a coating layer and a capsule shell, wherein

[0052] Described pellet is made up of following component and parts by weight thereof:

[0053] Nepeta 50 parts, Mint 15 parts, Fangfeng 25 parts, Perilla leaves 15 parts, Pueraria 25 parts, Bellflower 15 parts, Angelica dahurica 15 parts, Kudiding 50 parts, Reed root 40 parts, Bupleurum 25 parts, Bitter almonds 20 parts, 2 parts of chitosan-g-lactose, 3 parts of β-cyclodextrin, 1 part of starch, 2 parts of hydroxypropyl cellulose, 90 parts of water and 10 parts of ethanol solution with a volume fraction of 90%;

[0054] The coating layer consists of the following components and parts by weight thereof:

[0055] 12.5 parts of hypromellose, 2 parts of glyceryl triacetate, 3 parts of magnesium stearate and 55 parts of ethanol solution with a volume fraction of 90%.

[0056] The preparation method of the chitosan-g-lactose i...

Embodiment 3

[0059] Embodiment 3 A kind of Ganmao Qingre Capsule

[0060] The Ganmao Qingre Capsule consists of pellets, a coating layer and a capsule shell, wherein

[0061] Described pellet is made up of following component and parts by weight thereof:

[0062] 60 parts of nepeta, 20 parts of mint, 30 parts of windproof, 20 parts of perilla leaves, 30 parts of kudzu root, 20 parts of bellflower, 20 parts of angelica dahurica, 60 parts of Kudiding, 50 parts of reed root, 30 parts of Bupleurum, bitter almond 25 parts, 3 parts of chitosan-g-lactose, 5 parts of β-cyclodextrin, 1.5 parts of starch, 3 parts of hydroxypropyl cellulose, 95 parts of water and 15 parts of ethanol solution with a volume fraction of 95%;

[0063] The coating layer consists of the following components and parts by weight thereof:

[0064] 15 parts of hypromellose, 3 parts of triacetin, 5 parts of magnesium stearate and 60 parts of ethanol solution.

[0065] The ethanol solution is an aqueous ethanol solution with ...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a Ganmao Qingre capsule and a preparation method thereof. The invention discloses a Ganmao Qingre capsule. The Ganmao Qingre capsule comprises the following components and parts by weight: 40-60 parts of nepeta panicles, 10-20 parts of mint, 20-30 parts of Fangfeng, and 10-30 parts of perilla leaves 20 parts, Pueraria 20‑30 parts, Bellflower 10‑20 parts, Angelica dahurica 10‑20 parts, Kudiding 40‑60 parts, Reed root 30‑50 parts, Bupleurum 20‑30 parts, Bitter almond 15‑25 parts, 1-3 parts of modified chitosan, 1-5 parts of β-cyclodextrin, 0.5-1.5 parts of starch, 1-3 parts of hydroxypropyl cellulose, 85-95 parts of water and 5-15 parts of ethanol solution. The Ganmao Qingre Capsule prepared by the invention has the advantages of low hygroscopicity, good stability, high bioavailability, easy disintegration, good clinical curative effect, high fluidity of drug powder in the preparation process, and uniform capsule quality.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a Ganmao Qingre capsule and a preparation method thereof. Background technique [0002] Cold is a common disease, the main symptoms are headache, fever, cough, nasal congestion, sore throat, etc., which will affect work and life to a certain extent, and even cause complications, resulting in life-threatening. The common dosage forms of existing cold medicines are granules, capsules, tablets, etc. The process of existing capsules generally adopts the following methods, firstly the identification of medicinal materials, processing, drying, and then conventional pulverization, extraction, and then through the granulation process After granulation, sorting and general mixing, it is made into capsules. However, the existing granulation process is usually indeterminate, the particles are scattered and broken, the shape is poor, the fluidity is poor, a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K36/899A61K47/69A61K47/36A61K47/38A61P11/00A61P29/00
CPCA61K9/5047A61K36/232A61K36/233A61K36/238A61K36/346A61K36/488A61K36/534A61K36/535A61K36/538A61K36/66A61K36/736A61K36/899A61K47/36A61K47/38A61K2236/331A61K2236/39A61K2300/00
Inventor 张永谦梁志军程燕张坤黄信曾胜
Owner GUANGDONG YILI LUODING PHARMA
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