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Mometasone furoate gel and preparation method thereof

A technology of mometasone furoate and gel, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve the problems of affecting patient compliance, high impurity content, poor moisturizing effect, etc. problem, to achieve good moisturizing effect, good stability, and improved water loss rate

Active Publication Date: 2021-08-10
GUANGZHOU BAIYUNSHAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the mometasone furoate gel prepared by the existing prescription and process has high impurity content, high water loss rate, and poor moisturizing effect after being placed for a long time, which affects the compliance of patients when taking medicine.

Method used

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  • Mometasone furoate gel and preparation method thereof
  • Mometasone furoate gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Preparation of gel matrix: Take 9 parts by mass of Carbomer 980NF and disperse in purified water to swell for 3 hours, stir at 600 rpm for 100 min until uniformly dispersed, add 3 parts by mass of triethanolamine, and stir at 600 rpm until transparent gel , to get the gel matrix;

[0030] (2) Preparation of the main drug solution: get 40 parts by mass of polysorbate 80, 100 parts by mass of propylene glycol and 70 parts by mass of ethanol and mix evenly, then add 0.5 parts by mass of ethylparaben and 1 part by mass of mometasone furoate, Stir at 400rpm for 8min, dissolve at 25°C for 30min to obtain the main drug solution;

[0031] (3) Configuration of acid solution: 0.5 parts by mass of phosphoric acid is mixed with purified water to form an acid solution with a mass fraction of 1%;

[0032] (4) Add the acid solution obtained in step (3) to the gel matrix obtained in step (1), stir for 8 minutes at 50 rpm, then add the main drug solution obtained in step (2), and s...

Embodiment 2

[0034] The difference from Example 1 is that the mass parts of carbomer 980NF added in step (1) is 7.5, the mass parts of triethanolamine is 3, the mass parts of phosphoric acid added in step (3) is 0.4, make up to 1000 parts with purified water , and the rest are the same.

Embodiment 3

[0036] The difference from Example 1 is that the mass parts of carbomer 980NF added in step (1) are 7.5, the mass parts of triethanolamine are 2.5, the mass parts of phosphoric acid added in step (3) are 0.5, and the purified water is used to make up to 1000 parts , and the rest are the same.

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PUM

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Abstract

The invention discloses mometasone furoate gel and a preparation method thereof, and belongs to the technical field of external pharmaceutical preparations. The mometasone furoate gel is prepared from the following components in parts by weight: 0.5 to 2 parts of mometasone furoate, 5 to 12 parts of water-soluble matrix, 30 to 50 parts of cosolvent, 80 to 120 parts of humectant, 0.1 to 1 part of preservative, 50 to 90 parts of solvent, 1 to 5 parts of consistency regulator, 0.2 to 0.55 part of acids and 615 to 840 parts of purified water. The preparation method disclosed by the invention is simple to operate, and the prepared mometasone furoate gel is fresh and cool in skin feeling, not easy to separate out impurities, good in stability and high in safety.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations for external use, and in particular relates to a mometasone furoate gel and a preparation method thereof. Background technique [0002] Mometasone furoate is a synthetic corticosteroid hormone drug, which has anti-inflammatory, anti-allergic, anti-itching and reducing exudation effects, and can eliminate fever, redness and swelling symptoms caused by local inflammatory reactions. It is clinically applicable to various diseases that are effective for corticosteroid therapy, such as acute urticaria, neurodermatitis, seborrheic dermatitis, allergic dermatitis, chronic eczema, insect bite dermatitis, systemic lupus erythematosus, pemphigus, etc. [0003] Most of the mometasone furoate preparations currently on the market are cream preparations, and the stability of cream preparations is more likely to be affected, and the phenomenon of layering is more likely to occur, and cream pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/573A61K47/32A61P17/02A61P17/04A61P17/08A61P29/00A61P37/02A61P37/08
CPCA61K31/573A61K9/06A61K9/0014A61K47/32A61P29/00A61P37/08A61P17/04A61P17/08A61P37/02A61P17/02Y02A50/30
Inventor 朱岁华陈溪黄芷茵周洁高燕陈贤安王智森
Owner GUANGZHOU BAIYUNSHAN PHARM CO LTD
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