Efficient antibacterial honey paste and preparation method thereof

A technology of honey ointment and honey, which is applied in the direction of local antibacterial agents, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve problems such as difficulty in ensuring biological safety, limited use range, and difficulty in preparation. Achieve excellent antibacterial and anti-inflammatory effects, easy to store and use, and simple preparation methods

Inactive Publication Date: 2021-08-31
RENMIN UNIVERSITY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The fluidity of honey greatly limits the direct use of honey, making it difficult to use on human skin and the surface of articles. The current common method is to make it into a dressing for application. For example, patent CN201821963150.2 uses honey to prepare a kind of medicinal patch. Or pour honey into the hydrogel as in patent CN201711458706.2
But these products all face similar problems, that is, complex structure, difficult preparation, high price, difficult storage, and poor curative effect. Therefore, dressing products prepared from honey are only seen on paper, and no commercial products have been seen.
Recently, some products such as patent CN201711396730.8 mix honey with thickeners and additives to increase its viscosity so that it does not flow, but the viscosity is too large to limit its scope of use. More importantly, the content of honey used in this type of product is generally low. more than 50%, and the thickener is difficult to guarantee its biological safety, so the curative effect of this kind of product is still very low, it is difficult to pass the drug GMP certification
Some people also start with equipment, such as patent CN201220477701.0, which prepares a special toothpaste tube to hold honey, but this kind of product still does not solve the problem that the honey is too thin to stay in the wound for a long time

Method used

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  • Efficient antibacterial honey paste and preparation method thereof
  • Efficient antibacterial honey paste and preparation method thereof
  • Efficient antibacterial honey paste and preparation method thereof

Examples

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preparation example Construction

[0038] In the above preparation method, the honey is selected from common commercially available honey, including but not limited to Manuka honey.

[0039] Through a lot of experimental research, it is found that New Zealand Mankalu honey is better.

[0040] In the above preparation method, the cellulose includes but not limited to bacterial cellulose, bamboo fiber, pea fiber, sugarcane fiber and the like.

[0041] In step 1), the mass ratio of honey to bacterial cellulose can be: 100:30-100:0.1, specifically 100:0.1-100:10, more specifically 100:0.1, 100:1 or 100:10 .

[0042] In step 2), the rotational speed may be: 100r / min-4000r / min, and the temperature may be 30-50°C.

[0043] Honey ointment and ointment made from the above-mentioned honey paste also belong to the protection scope of the present invention.

[0044] The measuring method of fluidity in the following examples is: take a certain amount of product (such as 5g) and put it on the table, and see if there is an...

Embodiment 1

[0046] (1) The used raw material of honey ointment is made up of as follows in the present embodiment, by mass:

[0047] Honey: Manuka Honey 100 parts

[0048] Bacterial cellulose 0.1 parts

[0049] (2) The preparation steps are as follows:

[0050] Mix honey and bacterial cellulose according to the above ratio, make it evenly mixed at a rotating speed of 500r / min and at 40 degrees Celsius, cool, and pack into the ointment.

Embodiment 2

[0052] The same steps as in Example 1, wherein the ratio of honey to bacterial cellulose is 100:1.

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Abstract

The invention discloses an efficient antibacterial honey paste and a preparation method thereof. The preparation method comprises the following steps: 1) mixing honey and cellulose in proportion; 2) uniformly mixing the product obtained in the step 1) at a certain rotating speed and a certain temperature; and 3) cooling and packaging. The efficient antibacterial honey paste is free of any chemical additive, green, safe and free of toxic and side effects, can be directly applied to a human body and has excellent antibacterial property, the content of honey is 50% or above, the preparation method is simple and effective, a tedious preparation process is avoided, meanwhile, the product can be effectively adhered to skin and any wound surface, long term antibacterial effect is achieved, and in addition, the honey paste can be squeezed out through the paste, so that the honey paste is convenient to store and use.

Description

technical field [0001] The invention relates to a high-efficiency antibacterial honey ointment and a preparation method thereof, belonging to the field of antibacterial and anti-inflammatory medicines. Background technique [0002] As an excellent antibacterial agent, honey has been widely recognized in the academic and medical fields, but currently in the field of medical care, honey is usually mixed with other substances such as traditional Chinese medicine, ingredients, fruits, food additives, etc., and used as an auxiliary material in various healthcare products. Because the content of honey is too small, it is difficult to show the antibacterial effect. What's more, some products have been sterilized at high temperature before use, which seriously destroys the active ingredients of honey and makes it lose the antibacterial effect. Therefore, there is not any antibacterial product based on honey on the direct market. [0003] The fluidity of honey greatly limits the di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/644A61K9/06A61K47/38A61P31/02A61P29/00A61P17/02A61P17/10
CPCA61K35/644A61K9/06A61K47/38A61P31/02A61P29/00A61P17/02A61P17/10
Inventor 王亚培潘乾灏陶行磊
Owner RENMIN UNIVERSITY OF CHINA
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