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Application of polymer nanoprobe based on perflubron

A perfluorooctane and nanoprobe technology is applied in the application field of polymer nanoprobes and can solve the problems of high cost and complex synthesis of contrast agents.

Active Publication Date: 2021-09-10
INNOVATION ACAD FOR PRECISION MEASUREMENT SCI & TECH CAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the current research, it is rare to achieve multiple functions of a probe, and a contrast agent can be used as both 19 A contrast agent for F, which can also be used as 129 Xe contrast, and the current 129 The synthesis of Xe contrast agent is complicated and the cost is high

Method used

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  • Application of polymer nanoprobe based on perflubron
  • Application of polymer nanoprobe based on perflubron
  • Application of polymer nanoprobe based on perflubron

Examples

Experimental program
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Embodiment 1

[0024] The polymer nanoprobe based on perfluorooctyl bromide is prepared by emulsification method, and the specific method is as follows:

[0025] Dissolve 50 mg of poly(lactic-co-glycolic acid) (PLGA, Mw 7000) in 2 mL of dichloromethane, followed by adding 200 μL of perfluorooctyl bromide (PFOB) and 4 mL of emulsifier 5% (mass fraction) PVA, and then ultrasonic emulsification 40min (power 130W), after ultrasonic emulsification is completed, drop into 10mL ultrapure water, stir at room temperature to volatilize dichloromethane, centrifuge at 4°C and 14800rpm for 10min, and wash the obtained solid with ultrapure water 3 times The above PVA was removed to obtain the perfluorooctyl bromide-based polymer nanoprobe, which was denoted as PFOB@PLGA, and the mother liquor was obtained after dispersion in ultrapure water, and the mother liquor was stored at 4°C for future use.

[0026] Scan the PFOB@PLGA prepared in this example with a transmission electron microscope, and the resultin...

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Abstract

The invention discloses application of a polymer nanoprobe based on perflubron. The nanoprobe has good biological safety and 19F nuclear magnetic resonance imaging effect, while 129Xe has high solubility in PFOB and can detect a strong 129Xe signal, so that the probe can be used as a 129Xe MRI contrast agent and a 19F MRI contrast agent at the same time, and has good medical research and application prospects.

Description

technical field [0001] The invention belongs to the technical field of magnetic resonance imaging, and in particular relates to the application of a polymer nanoprobe based on perfluorooctyl bromide. Background technique [0002] With the aging and rapid growth of the population, the number of cancer cases and deaths worldwide is also increasing rapidly. Cancer will be the leading cause of death in the 21st century and will be the most important obstacle to increasing life expectancy in countries around the world. Among the 185 countries or regions in the world, the incidence and death of cancer in China are at the upper-middle level; the incidence and mortality of gastric cancer, lung cancer, and liver cancer account for about half of the world's total. The root of the gap lies in the low rate of early diagnosis and early treatment of cancer patients in our country. At present, molecular imaging is the main method for cancer diagnosis. These imaging techniques can accurat...

Claims

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Application Information

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IPC IPC(8): A61K49/18A61K49/12B82Y25/00
CPCA61K49/1818A61K49/126B82Y25/00
Inventor 周欣王瑞芳陈世桢丘茂松叶朝辉
Owner INNOVATION ACAD FOR PRECISION MEASUREMENT SCI & TECH CAS
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