Spine internal fixing device containing carrier for implanting antituberculous drugs into artificial bone in sustained-release mode

Abstract

The invention discloses a spinal internal fixing device containing a carrier for implanting antituberculous drugs into an artificial bone in a sustained-release mode. The spinal internal fixing device containing the carrier for implanting the antituberculous drugs into the artificial bone in a sustained-release mode comprises fixing screws arranged at intervals and a connecting rod connecting the two fixing screws, wherein tuberculosis treatment drugs are arranged in the fixing screws and / or the connecting rod, the outer wall of each fixing screw and the outer wall of the connecting rod are provided with drug passing holes allowing the tuberculosis treatment drugs to be released, positioning devices used for fixing the tuberculosis treatment drugs are arranged in the fixing screws and the connecting rod, and the tuberculosis treatment drugs comprise a slow-release drug carrier, isoniazide, rifampicin and streptomycin.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a spinal internal fixation device containing an anti-tuberculosis drug slow-release implanted artificial bone carrier. Background technique [0002] Bone and joint tuberculosis is a bone and joint-specific infection caused by Mycobacterium tuberculosis, accounting for about 5% to 10% of systemic tuberculosis infections, of which spinal tuberculosis is the most common form. Anti-tuberculosis drugs are the basis of bone and joint tuberculosis treatment. [0003] The methods for the treatment of bone and joint tuberculosis can be roughly divided into drug systemic therapy and local surgical treatment. The purpose of surgical treatment is mainly to remove sequestrum, remove tuberculous abscess to relieve nerve compression, and maintain spinal stability. However, although surgery can remove local tuberculosis lesions, it cannot completely eliminate tuberculosis infection, and posto...

AI Technical Summary

Problems solved by technology

The above-mentioned methods are to make the drug reach the lesion through blood circulation to achieve the purpose of killing tuberculosis, but the pathogenesis of bone and joint tuberculosis determines that tuberculosis forms a large amount of pus, caseous necrotic tissue, sequestrum and sclerosis at the lesion. The disorder of bone and local pathological structure leads to insufficient blood supply of the focus, so that the drug cannot reach the minimum inhibitory concentration (Minimal inhibitory concentration, MIC) of anti-tuberculosis bacteria in the tuberculosis focus, that is, the effective bactericidal concentration, and the continuous low Drug concentration can even induce the occurrence of drug resistance

At present, there is a Chinese patent authorization announcement number CN104107086B which discloses a pedicle screw with the function of precise and sustained drug dose release. Although this patent has a certain drug dose sustained release function, it uses the body temperature-memory alloy control as the start and release control. The slow-release time of the device is relatively short. When the body temperature-memory alloy control works, it will release all the drugs in a short time. The drug-loading system may not be able to release stably for a long time, and cannot form long-term stable drugs at the tuberculosis focus. Concentration, unable to completely kill Mycobacterium tuberculosis, and even induce drug resistance

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