Combined detection method of virus neutralizing antibody and non-neutralizing antibody, detection card and application
A technology of antibody detection and joint detection, which is applied in the field of biomedical detection, can solve the problems of inability to distinguish neutralizing antibodies from non-neutralizing antibodies, poor specificity, and low detection sensitivity of neutralizing antibodies, achieving fast detection speed and improving specificity , the effect of high sensitivity
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Embodiment 1
[0081] A detection card for SARS-CoV-2 neutralizing antibody and non-neutralizing antibody, the detection card includes a chromatographic test paper, a housing and a sample diluent, and the chromatographic test paper includes a bottom plate, a sample pad 1, a binding pad 2, NC membrane 3 and water-absorbing pad 4, the sample pad 1, binding pad 2, NC membrane 3 and water-absorbing pad 4 are sequentially pasted on one side of the bottom plate; the NC membrane 3 is sequentially provided with non-neutralizing antibody detection lines 5, Neutralizing antibody detection line 6 and quality control line 7, the non-neutralizing antibody detection line 5 is close to the binding pad 2, the quality control line 7 is close to the water-absorbing pad 4, and the non-neutralizing antibody detection line 5 is coated with RBD - ACE2 protein binding complex, the detection line 6 is coated with RBD protein; the binding pad is provided with RBD protein markers and chicken IgY markers, the label car...
Embodiment 2
[0091] A detection card for SARS-CoV-2 neutralizing antibody and non-neutralizing antibody, comprising chromatography test paper, housing and sample diluent, said chromatography test paper comprising bottom plate, sample pad, binding pad, NC membrane and water-absorbing pad , the sample pad, binding pad, NC membrane and water-absorbent pad are pasted on one side of the bottom plate in sequence; the NC membrane is provided with a non-neutralizing antibody detection line, a neutralizing antibody detection line and a quality control line in sequence, and the non-neutralizing antibody detection line and quality control line are sequentially arranged on the non-neutralizing antibody The neutralizing antibody detection line is close to the binding pad, the quality control line is close to the water-absorbing pad, the non-neutralizing antibody detection line is coated with RBD-ACE2 protein binding complex, and the neutralizing antibody detection line is coated with RBD protein; The bi...
Embodiment 3
[0095] A detection card for SARS-CoV-2 neutralizing antibody and non-neutralizing antibody, comprising chromatography test paper, housing and sample diluent, said chromatography test paper comprising bottom plate, sample pad, binding pad, NC membrane and water-absorbing pad , the sample pad, binding pad, NC membrane and water-absorbent pad are pasted on one side of the bottom plate in sequence; the NC membrane is provided with a non-neutralizing antibody detection line, a neutralizing antibody detection line and a quality control line in sequence, and the non-neutralizing antibody detection line and quality control line are sequentially arranged on the non-neutralizing antibody The neutralizing antibody detection line is close to the binding pad, the quality control line is close to the water-absorbing pad, the non-neutralizing antibody detection line is coated with RBD-ACE2 protein binding complex, and the neutralizing antibody detection line is coated with RBD protein; The bi...
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