Bimodal interference compensation circuit for neural signal acquisition

Abstract

A bimodal interference compensation circuit for neural signal acquisition comprises an electrical sensing circuit, a chemical sensing circuit, an interference compensation circuit and a control module. Neural electrical and neural chemical signals are respectively acquired through an electrical front-end sensing circuit and a chemical front-end sensing circuit, and between the two acquisition front ends, the interference compensation circuit is used for generating a proper conversion ratio to compensate electrical interference in chemical signals, so that simultaneous detection of the electroneurographic signals and the chemical signals is realized, and the precision of bimodal detection is improved.

Description

technical field [0001] The invention relates to the technical field of analog integrated circuits, in particular to a dual-mode interference compensation circuit for neural signal acquisition. Background technique [0002] With the rapid development of integrated circuit technology, neural signal acquisition chips based on integrated circuits are continuously used in neuroscience. Most of the current chips are based on single-mode acquisition of nerve electrical signals, which can only collect electrical signals of nerves, ignoring the chemical signals generated during the transmission of nerve signals, especially the neurotransmitters between nerve cells. Therefore, the traditional single-mode acquisition method will lead to incomplete acquisition of neural signals, and the simultaneous detection of neuroelectric and neurochemical dual-mode signals faces the problem of mutual interference between signals. [0003] The dual-mode interference problem is caused by the acquisi...

AI Technical Summary

Problems solved by technology

The electrical electrode is an inert metal with low resistance, which is insensitive to ion concentration and hardly subject to chemical interference; the surface of the chemical electrode is coated with an ion-sensitive film, which can absorb specific ions. When the ion concentration is high, a higher voltage value is generated. The voltage value is read out to realize the measurement of the chemical signal, but the ion-sensitive membrane is a high-impedance insulating material, which is equivalent to a capacitance with the solution and the electrode, causing the electrical signal to enter the chemical circuit through capacitive coupling, thereby causing interference

[0004] Due to the dual-mode interference problem, the current dual-mode circuit cannot realize the simultaneous detection of adjacent points. The specific performance is: 1. In space, the distance between the two electrodes is relatively long

The closer the distance between the electrical electrodes and the chemical electrodes, the greater the interference, and the farther the electrode distance reduces the interference, but reduces the electrode density, which is not conducive to the acquisition of nerve signals

2. In terms of time, the two circuits cannot be detected at the same time

The chemical signal will contain electrical interference, which affects the reading accuracy of the chemical signal

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