Unlock instant, AI-driven research and patent intelligence for your innovation.

Combinational medication

A technology for combining medicaments and compounds, applied in drug combinations, pharmaceutical formulations, anti-tumor drugs, etc.

Pending Publication Date: 2021-10-08
FUJIFILM CORP
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Expect new treatments for the disease

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Combinational medication
  • Combinational medication
  • Combinational medication

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0257] Hereinafter, the present invention will be described in further detail through examples, but the present invention is not limited to these examples.

[0258]

[0259] (S,E)-N-(1-((5-(2-((4-cyanophenyl)amino)-4-(propylamino) pyrimidin-5-yl)-4-pentyn-1-yl)amino)-1-oxopropan-2-yl)-4-(dimethylamino)-N-methyl-2-butenamide, and by The method described in the examples of the above-mentioned Patent Document 2 prepared succinate and used it in the following tests.

[0260]

[0261] As test substances, decitabine (hereinafter, also referred to as Decitabine or DEC), venetoclax (hereinafter, also referred to as Venetoclax or VEN), and a succinate salt of compound A1 were used.

[0262] Decitabine (Tokyo Chemical Industry Co., Ltd. Cat. #A2232), venetoclax (LC Laboratories Cat. #V-3579) and succinate of compound A1 were dissolved in dimethyl methylene Sulfone (DMSO) substance.

[0263] MV-4-11 cells, which are human FLT3-ITD mutation-positive leukemia cell lines, were subcul...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention addresses the problem of providing a combinational medication that exhibits a therapeutic effect suitable for practical use against tumors such as acute myeloid leukemia. The present invention provides a combinational medication containing: a compound represented by general formula [1] prescribed in the description, such as (S,E)-N-(1-((5-(2-((4-cyanophenyl)amino)-4-(propylamino)pyrimidin-5-yl)-4-pentyn-1-yl)amino)-1-oxopropan-2-yl)-4-(dimethylamino)-N-methyl-2-butenamide, or a salt thereof; and at least one selected from the group consisting of BCL-2 inhibitors and pyrimidine metabolism antagonists.

Description

technical field [0001] The present invention relates to a combined medicament for effectively treating blood cancer. Background technique [0002] Nitrogen-containing heterocyclic compounds that have excellent Fms-like tyrosine kinase 3 (FLT3) inhibitory activity and are effective as pharmaceutical raw materials have been reported (Patent Document 1 and Patent Document 2). Furthermore, a pharmaceutical composition for treating FLT3 mutation-positive cancer containing the nitrogen-containing heterocyclic compound has been reported (Patent Document 3). Furthermore, a method for producing a nitrogen-containing heterocyclic compound and an intermediate thereof have been reported (Patent Document 4). Hereinafter, the compound represented by the general formula [1] described in Patent Document 3 or its salt may be abbreviated as compound A in some cases. [0003] prior art literature [0004] patent documents [0005] Patent Document 5 describes a combination therapy of an imi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61P35/00A61P35/02A61P43/00A61K31/505
CPCA61P43/00A61K31/505A61P35/00A61P35/02A61K31/635A61K31/706A61K45/06A61K2300/00
Inventor 村尾英俊小椋隼人齐藤耕一萩原真二山浦刚中谷俊幸清井仁石川裕一
Owner FUJIFILM CORP