8 results about "Butenamide" patented technology

The present invention relates to a pharmaceutically acceptable salt of a tyrosine kinase inhibitor, a crystal, a preparation method, and a use, and in particular to a pharmaceutically acceptable salt of (E)-4-(dimethylamino)-N-(7-(2-ethoxyethoxy)-4-((3-ethynylphenyl)amino)-6-quinazolinyl)-2-butenamide, a crystal form and a preparation method therefor, and a pharmaceutical composition containing a therapeutically effective amount of the crystal form, and a use thereof in treating cancer.

The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.

The invention discloses a (2E, 4E)-5-(3, 4-dimethoxyphenyl)-N-phenylpent-2, 4-diene amide compound, and the structural formula of the compound is shown in the specification. The preparation method comprises the following steps: step 1, preparing N-phenylbutyl-2-alkenyl amide, step 2, preparing a (2E, 4E)-5-(3, 4-dimethoxyphenyl)-N-phenylpent-2, 4-dialkenyl amide compound, and step 3, preparing a (2E, 4E)-5-(3, 4-dimethoxyphenyl)-N-phenylpent-2, 4-dialkenyl amide compound. The (2E, 4E)-5-(3, 4-dimethoxyphenyl)-N-phenylpent-2, 4-dienamide compound is applied to the preparation of the medicine for treating epilepsy, and the medicine for treating epilepsy is applied to the preparation of the medicine for treating epilepsy. The compound prepared by the invention has higher anti-epileptic activity and lower neurotoxicity, can be used for preparing anti-epileptic drugs suitable for long-term administration, and successfully solves the problem that the existing drugs are easy to generate tolerance and side effects.

The invention discloses a levocarnitine refining method which comprises the following steps: mixing and heating a levocarnitine crude product and a recrystallization solvent until the levocarnitine crude product and the recrystallization solvent are completely dissolved, then cooling and crystallizing, and carrying out suction filtration, washing and drying to obtain high-purity levocarnitine, wherein the recrystallization solvent comprises a first solvent and a second solvent; the first solvent is at least one of tetrahydrofuran, acetone, acetonitrile, n-butyl alcohol, ethyl acetate and N, N-dimethylformamide; the second solvent is at least one of water and ethanol; the mass ratio of the first solvent to the second solvent is 1: (0.2-8). According to the method disclosed by the invention, 4-(trimethyl ammonium) butyl-2-olefine acid inner salt and 4-(trimethyl amino)-2-butenamide impurities with similar structures in the levocarnitine crude product can be effectively removed, the purity of the product reaches 99.5% or above, the product meets the pharmacopoeia standard, and the quality of the product has obvious competitiveness.

The present disclosure generally relates to various formulations and uses of the compound: (E)-N-(4-cinnamamidobutyl)-4-hydroxy-2-methylbut-2-enamide, which is also referred to as (2E)-4-hydroxy-2-methyl-N-(4-{[(2E)-3-phenyl-2-propenoyl]amino}butyl)-2-butenamide, and which is referred to herein as “TM1,” or any comestibly acceptable salts thereof. In some aspects, the disclosure provides compositions that include TM1, or a comestibly acceptable salt thereof. In some embodiments, the compositions are ingestible compositions, including, but not limited to, packaged food or beverage products. In some other aspects, the disclosure provides uses of TM1, or a comestibly acceptable salt thereof, for enhancing an umami taste or a kokumi taste of an ingestible composition. In some other aspects, the disclosure provides uses of TM1, or a comestibly acceptable salt thereof, for enhancing sweetness of an ingestible composition. In some other aspects, the disclosure provides uses of TM1, or a comestibly acceptable salt thereof, for enhancing a meaty taste of an ingestible composition. In some embodiments of these aspects, TM1, or a comestibly acceptable salt thereof, is used in combination with one or more umami or kokumi tastants.

The application belongs to the technical field of thickening agent preparation, and particularly relates to a preparation method of a thickening agent for fracturing. The preparation method of the thickening agent for fracturing comprises the following steps: (1) pre-emulsification treatment of dicyclopentadiene oxyethyl acrylate; (2) preparation of an aqueous phase; (3) preparation of an initiator solution; (4) polymerization reaction; and (5) post-treatment. The preparation method of the thickening agent for fracturing comprises the following steps: acrylamide is used as a main monomer, dicyclopentadiene oxyethyl acrylate, 4-[(3-methacrylamidopropyl)dimethylammonio]butane-1-sulfonate and isobutylene amide propyl trimethyl ammonium methyl sulfate are used as functional monomers to perform random copolymerization reaction, a multi-element random copolymerization structure of "rigid temperature-resistant chain segment-amphoteric ion salt-resistant chain segment-cationic adsorption chain segment" is constructed, and the prepared thickening agent for fracturing has excellent salt resistance, high-temperature resistance and high tackifying performance.

The invention discloses a preparation method of a coordination polymer containing CuII and research on the inhibition effect of the coordination polymer on soil urease and nitrifying bacteria, and relates to the technical field of fertilizer.The preparation method comprises the steps that 3-aminopyridine and fumaric acid serve as raw materials to synthesize N1, N4-bis (3-pyridyl)-2-butenamide, then CuCl2. 2H2O and the synthesized N1, N4-bis (3-pyridyl)-2-butenamide are used for preparing the coordination polymer containing CuII. The novel coordination polymer [Cu (3-bbpa) (5-HIPA). H2O] is synthesized from N, N, N, N ', N'-bis (3-pyridyl)-2-butenamide and 5-hydroxyisophthalic acid by a hydrothermal method, and the crystal structure of the novel coordination polymer [Cu (3-bbpa) (5-HIPA). H2O] is analyzed to research the influence of the novel coordination polymer as an inhibitor on soil urease and nitrifying bacteria. The difunctional inhibitor is studied to delay the conversion process of urea from urea nitrogen to ammonium nitrogen and ammonium nitrogen to nitrate nitrogen, overcomes the defect of single inhibition capability of a traditional inhibitor, is strong in inhibition capability, low in toxicity, low in cost and simple in synthesis method, can effectively improve the utilization rate and stability of the fertilizer urea, and has a wide application prospect. Nitrogen loss in agricultural activities is reduced, the fertilization cost is reduced, and the grain yield is increased.