A simple and efficient method for synthesizing 4-arylbutyric acid derivatives

A technology for aryl butyric acid and derivatives, which is applied in the field of simple and efficient synthesis of 4-aryl butyric acid derivatives, can solve the problems of too many additives, lengthy synthesis steps, harsh reaction conditions, etc., and solve the cumbersome steps of the synthesis process , high product yield and mild reaction conditions
CN112142660BActive Publication Date: 2021-11-23HUAIYIN TEACHERS COLLEGE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HUAIYIN TEACHERS COLLEGE
Publication Date
2021-11-23

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Abstract

The invention discloses a simple and efficient method for synthesizing 4-arylbutyric acid derivatives. Removable 8-aminoquinoline is used as a guiding group to control the regioselectivity of the reaction, and non-activated 3-butenamide is used. As a reaction raw material, it reacts with cheap, readily available, stable and efficient aryltrimethoxysilane to prepare and synthesize a series of functionalized 4-arylbutyric acid derivatives concisely and efficiently. The method has the advantages of simple operation, simple and easy-to-obtain reaction raw materials, easy separation and purification of products, high product yield and good reaction zone selectivity. The invention can provide related products for treating urea cycle disorder, novel anti-type II diabetes drugs, angiotensin-converting enzyme inhibitors and the like, and has good market potential and application value.
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Description

technical field

[0001] The invention belongs to the technical field of organic synthesis, and in particular relates to a simple and efficient method for synthesizing 4-aryl butyric acid derivatives. Background technique

[0002] Carboxylic acids and their derivatives are widely found in molecules such as medicines, pesticides, and natural products. Many carboxylic acids and their derivatives themselves are small organic drug molecules with specific physiological activities, and are used to treat leukemia, hypertension, ovarian cancer, common diseases such as diabetes. 4-Arylbutyric acid and its derivatives are one of the important categories, such as sodium phenylbutyrate (Buphenyl) is an important prodrug, which is used to treat urea cycle disorders, which can effectively reduce blood ammonia and blood glutamine Acid content; Chlorambucil is used to treat Hodgkin's disease, multiple non-Hodgkin's lymphomas, chronic lymphocytic leukemia, Waldenstrom's macroglobulinemia, and...

Claims

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