Bakuchiol-containing liposome and preparation method thereof

A bakuchiol and liposome technology is applied in the directions of liposome delivery, medical preparations of inactive ingredients, pharmaceutical formulations, etc. Skin irritation and other problems to improve poor stability, mild performance, brighten skin tone

Pending Publication Date: 2021-10-19
ZHEJIANG YIGE ENTERPRISE MANAGEMENT GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Wherein, the composition of liposome greatly affects its encapsulation efficiency and transdermal performance, and the ethanol content in liposome is very high, although can reduce the hydration force between liposome, excessive can cause liposome Aggregation and fusion, and ethanol is irritating to the skin and can easily cause allergic reactions, so it is not suitable for sensitive skin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0026] A liposome containing bakuchiol, the preparation method of which comprises the following steps:

[0027] Step 1. Weigh 5 parts of bakuchiol, 5 parts of lecithin and 1 part of cholesterol, add them to 10 parts of caprylic / capric triglyceride and 20 parts of 1,3-propanediol, stir and melt at 70°C , to obtain the oil phase; wherein the content of phosphatidylcholine in the lecithin is 70%;

[0028] Step 2: Weigh 2 parts of sodium acetylated hyaluronate, add it to 57 parts of water, stir and dissolve at 70°C to obtain the water phase;

[0029] Step 3: Add the oil phase to the water phase, stir for 30 minutes to obtain a preliminary mixed solution, and then use a high-pressure homogenizer to homogeneously circulate the preliminary mixed solution for 5 times under the condition of 1000 bar to obtain the lipid containing bakuchiol body.

[0030] Among them, bakuchiol can be selected: the CAS of bakuchiol is 10309-37-2, which is light yellow oily liquid with a purity of 99%. ...

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Abstract

The invention discloses a bakuchiol-containing liposome and a preparation method thereof. The bakuchiol-containing liposome is prepared from, by weight, 3 to 8 parts of bakuchiol, 3 to 8 parts of lecithin, 0.5 to 1.5 parts of cholesterol, 5 to 15 parts of caprylic/capric triglyceride, 15 to 30 parts of 1, 3-propylene glycol, 1 to 3 parts of acetylated sodium hyaluronate and 50 to 65 parts of water. The preparation method comprises the following steps: adding bakuchiol, lecithin and cholesterol into caprylic/capric triglyceride and 1, 3-propylene glycol, and melting to obtain an oil phase; adding acetylated sodium hyaluronate into water, and dissolving to obtain a water phase; and adding the oil phase into the water phase, and homogenizing at high pressure to obtain the psoralen-containing liposome. The bakuchiol-containing liposome has the characteristics of small skin irritation and good transdermal absorption effect.

Description

technical field [0001] The invention relates to a bakuchiol liposome, in particular to a bakuchiol-containing liposome and a preparation method thereof. Background technique [0002] Bakuchiol is a phenolic substance extracted from the herbaceous plant Bakuchili Seed. It is a prenylphenol terpenoid compound. It has been found in experimental studies and clinical trials that it has oil control, anti-inflammatory, and anti-acne effects. Active, also has anti-oxidation, anti-aging, whitening effects, can improve wrinkles, reduce pigmentation, and has high safety. However, the storage conditions of bakuchiol are relatively harsh and easy to oxidize, and due to the existence of the cuticle of the skin, when bakuchiol directly acts on the skin, its absorption will be greatly restricted, the transmission rate is low, and transdermal absorption The effect is poor, thereby affecting the application of bakuchiol. [0003] Liposome, which is composed of phospholipids, 20%-50% ethanol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K47/10A61K47/24A61K47/28A61K47/36A61K31/05A61P17/00A61P17/10A61P17/18A61P17/16
CPCA61K9/1277A61K9/1272A61K47/10A61K47/24A61K47/28A61K47/36A61K31/05A61P17/00A61P17/10A61P17/18A61P17/16
Inventor 张大勇毕永贤杜雨涵刘金俊周浩淼李昊
Owner ZHEJIANG YIGE ENTERPRISE MANAGEMENT GRP CO LTD
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