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Peripheral nerve composite catheter as well as preparation method and application thereof

A technology of peripheral nerves and catheters, which is applied in the fields of pharmaceutical formulations, medical science, and prostheses, and can solve problems such as unsatisfactory recovery of regenerative nerve function, affecting nerve repair effects, and inability to load drugs, cells, and growth factor components. To achieve the effect of consolidating catheter strength, enhancing adhesion and migration, and high mechanical compressive strength

Active Publication Date: 2021-11-12
NKD PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the recovery effect of the existing nerve conduits on regenerative nerve function is not ideal. For example, patent CN 202010415408.0 adopts electrospinning and coaxial co-spinning to prepare oriented nanomembranes with a shell-core structure, and then winds them into bionic nerve bridges, which cannot load drugs, Cell and growth factor components
Patent CN 201510822838.3 disperses the nerve growth factor in the polymer to prepare an inner and outer cannula nerve bridge tube. The outer layer has no orientation to play a supporting role, and the inner layer is oriented to guide cell growth. However, due to the limitation of the hydrophilicity of the polymer, nerve growth The slow release of factors affects the effect of nerve repair

Method used

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  • Peripheral nerve composite catheter as well as preparation method and application thereof
  • Peripheral nerve composite catheter as well as preparation method and application thereof
  • Peripheral nerve composite catheter as well as preparation method and application thereof

Examples

Experimental program
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preparation example Construction

[0067] In the preparation method of oriented nanofiber membrane 2 in some embodiments, a mixture of tetrahydrofuran and N,N-dimethylformamide in a volume ratio of 6:4-7:3 is used as a solvent, and the volume of the two can be 6 :4 or 7:3.

[0068] In some embodiments, the filaments in the hollow oriented tubule 3 are in an oriented state.

[0069] In some embodiments, the hollow oriented tubule 3 is wound from an oriented nanofiber film made of fiber filaments.

[0070] In some embodiments, the length of the hollow alignment tubule 3 is 1-5 cm.

[0071] In some embodiments, the inner diameter of the hollow alignment tubule 3 is 0.5-2.0 mm, and the thickness is 0.05-0.5 mm. Research has found that for the hollow oriented tubules 3, if the thickness of the oriented nanofiber film is too thick, it is not easy to adhere to itself; if the thickness is too thin, the compression resistance after the film is rolled into a tube is too poor to meet the needs of use. If the inner diam...

Embodiment 1

[0084] Such as figure 1 As shown, this embodiment provides a composite catheter for peripheral nerves, including a nanofiber porous hollow outer tube as a supporting cavity; an oriented nanofiber membrane attached to the inner wall of the nanofiber porous hollow outer tube to form a cavity for promoting Nerve oriented docking and regeneration; hollow oriented tubules, built into the cavity formed by the oriented nanofiber membrane, are used to strengthen the compression resistance and orientation of the peripheral nerve composite conduit, and guide the orderly growth of nerves; hydrogel Columns, embedded in hollow oriented tubules.

[0085] The specific preparation method of the peripheral nerve composite catheter in this embodiment is as follows:

[0086] 1) Preparation of nanofiber porous hollow outer tube

[0087] Adopt polylactic acid-polycaprolactone copolymer (PCL molar content 10%) as starting raw material, viscosity 1.0dl / g, THF and N,N-dimethylformamide as solvent (...

Embodiment 2

[0100] Such as figure 1 As shown, this embodiment provides a composite catheter for peripheral nerves, including a nanofiber porous hollow outer tube as a supporting cavity; an oriented nanofiber membrane attached to the inner wall of the nanofiber porous hollow outer tube to form a cavity for promoting Nerve oriented docking and regeneration; hollow oriented tubules, built into the cavity formed by the oriented nanofiber membrane, are used to strengthen the compression resistance and orientation of the peripheral nerve composite conduit, and guide the orderly growth of nerves; hydrogel Columns, embedded in hollow oriented tubules.

[0101] The specific preparation method of the peripheral nerve composite catheter in this embodiment is as follows:

[0102] 1) Preparation of nanofiber porous hollow outer tube

[0103] Using polylactic acid-polycaprolactone copolymer (PCL molar content 10%) as the starting material, the viscosity is 1.0dl / g; using tetrahydrofuran and N,N-dimet...

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Abstract

The invention relates to a peripheral nerve composite catheter as well as a preparation method and application thereof. The peripheral nerve composite catheter comprises a nanofiber porous hollow outer tube serving as a supporting cavity; an oriented nanofiber membrane which is attached to the inner wall of the nanofiber porous hollow outer tube to form a cavity and is used for promoting directional butting and regeneration of nerves; a hollow oriented tubule which is arranged in the cavity formed by the oriented nanofiber membrane and is used for enhancing the pressure resistance and the orientation of the peripheral nerve composite catheter and guiding the nerve to grow orderly; and a hydrogel column which is arranged in the cavity of the hollow oriented tubule, wherein the nanofiber porous hollow outer tube, the oriented nanofiber membrane and the hollow oriented tubule are all prepared by an electrostatic spinning process. The peripheral nerve composite conduit provided by the invention can automatically adjust and release blood vigorous cells or neurotrophic factors according to nerve growth characteristics, and can solve the problem of nerve fiber regeneration and repair after nerve defect at present.

Description

technical field [0001] The invention relates to a peripheral nerve composite catheter and a preparation method and application thereof. Background technique [0002] Peripheral nerve injury is a common type of injury with a high incidence and disability rate, among which defect injury is the most common type of injury. For a small number of defects, tension-free suturing at the broken ends is possible. For larger defects, autologous nerve transplantation is still the first choice for clinical treatment, but the results after repair are not ideal, especially for long-term defects (>6mm). [0003] Nerve bridging catheters can be used to repair long-distance peripheral nerve defects, which is a hot research direction at present, and various nerve catheters and optimization design ideas are emerging. However, the recovery effect of the existing nerve conduits on regenerative nerve function is not ideal. For example, patent CN 202010415408.0 adopts electrospinning coaxial co-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/00A61L27/18A61L27/38A61L27/50A61L27/54
CPCA61F2/0059A61F2/0077A61L27/18A61L27/383A61L27/3834A61L27/3878A61L27/50A61L27/54A61L2430/32A61L2300/602A61L2300/412A61L2400/12A61L2300/414C08L71/02C08L67/04
Inventor 郭杰冷鸿飞徐小雨陶秀梅
Owner NKD PHARMA CO LTD
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