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Method for synthesis of diazabicyclo[6.2.0]decane related compounds

A compound and nitrogen protection technology, applied in the field of synthesizing diazabicyclo[6.2.0]decane-related compounds, can solve the problems of low yield, limited synthetic route, lengthy and the like

Pending Publication Date: 2021-11-16
EISIA R&D MANAGEMENT CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0014] However, tedious, low-yielding and / or expensive synthetic routes limit the application of this compound

Method used

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  • Method for synthesis of diazabicyclo[6.2.0]decane related compounds
  • Method for synthesis of diazabicyclo[6.2.0]decane related compounds
  • Method for synthesis of diazabicyclo[6.2.0]decane related compounds

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Embodiment Construction

[0153] While the terms used herein are considered to be well understood by those of ordinary skill in the art, definitions are set forth herein to facilitate the interpretation of the subject matter disclosed herein.

[0154] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the subject matter disclosed herein belongs. Although any methods, devices, and materials similar or equivalent to those described herein can be used in the practice or testing of the presently disclosed subject matter, representative methods, devices, and materials are described herein.

[0155] All method combinations or process steps used herein can be performed in any order, unless otherwise stated or clearly implied to the contrary in the context in which the recited combination is made.

[0156] The methods and apparatus of the present disclosure (including components thereof) may comprise...

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Abstract

A method for the synthesis of diazabicyclo[6.2.0]decane compounds is provided. The synthesis proceeds by stereoselective synthesis of a chiral lactone followed by azetidine formation via a series of chemoselective reactions. Bicyclization results with the formation of diazobicyclo[6.2.0]decane related compounds.

Description

[0001] statement of government support [0002] This invention was made with government support awarded by the US Department of Defense Peer Reviewed Medical Research Program (Grant No. W81XWH-16-1-0719). The government has certain rights in this invention. [0003] Cross References to Related Applications [0004] This application claims priority to U.S. Provisional Patent Application No. 62 / 790,340, filed January 9, 2019, which is incorporated herein by reference. technical field [0005] The present invention relates to a stereochemically defined synthesis for the production of 1,6-diazabicyclo[6.2.0]decane. Background technique [0006] Malaria is an infectious disease caused by protozoan parasites of the genus Plasmodium. The reason why malaria is difficult to cure is the complex life cycle of Plasmodium and the emergence of parasite drug resistance. Diversity-oriented synthesis (DOS) has been used to identify antimalarial compounds. For example, the phenylalanyl-t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D487/04C07D491/147C07D203/12C07D205/04C07D307/33C07D317/28C07C229/36C07C247/10
CPCC07D487/04C07D491/147C07D317/28C07D205/04C07D307/33C07D203/12C07C247/10C07B2200/07C07C231/12C07C313/06C07C303/40C07C233/51C07C311/18C07D403/06C07D405/14
Inventor 方家范B·米塔塞夫J·杨
Owner EISIA R&D MANAGEMENT CO LTD
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