Compositions and methods using combination of calcium and at least one of oleuropein or metabolite thereof

A technology of oleuropein and metabolites, applied in compositions for improving and maintaining muscle function or reducing loss of muscle function, at least one combination to enhance the field, capable of solving problems such as difficulty in taking preventive or therapeutic measures
CN113677333APending Publication Date: 2021-11-19SOC DES PROD NESTLE SA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SOC DES PROD NESTLE SA
Publication Date
2021-11-19

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Abstract

A combination of calcium and at least one of oleuropein or metabolite thereof can be orally administered to an individual in an amount effective to achieve at least one result that is (i) improved mitochondrial calcium uptake in muscle cells, (ii) improved utilization of calcium in muscle cells, (iii) increased mitochondrial energy in muscle cells, (iv) improvement in at least one of muscle functionality, muscle performance, or muscle strength, (v) decreased muscle fatigue, (vi) increased mobility, and / or (vii) treatment of a muscle disorder linked to calcium depletion or deficiency. The individual can be at least one of an aging subject; an elderly subject; a subject with muscle fatigue or muscle weakness; a subject with impaired mobility; a frail subject; a pre-frail subject; a sarcopenic subject; a subject recovering from pre-frailty, frailty, sarcopenia or impaired mobility; a subject undergoing physical rehabilitation; a sportsman; or a pet.
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Description

Background technique

[0001] The present disclosure generally relates to compositions and methods using calcium in combination with at least one of oleuropein or its metabolites. More specifically, the present disclosure relates to enhancing bioenergetics and mitochondrial function by combining calcium with at least one of oleuropein or its metabolites to promote mitochondrial calcium import, which in turn can enhance muscle contraction and muscle performance, thereby improving . Compositions and methods for maintaining muscle function or reducing loss of muscle function.

[0002] Sarcopenia is defined as age-related loss of muscle mass and function, including muscle strength and walking speed. Muscle function and physical capacity decline with loss of muscle mass. The incidence of loss of mobility, disability, and death at advanced age is highly predicted by impaired muscle function. Sarcopenia is becoming more prevalent with a growing geriatric population, with 45% of the ...

Claims

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