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Compound traditional Chinese medicine for treating inflammatory pain and preparation method thereof

The technology of medicine and medicinal liquid is applied in the field of compound traditional Chinese medicine for treating inflammatory pain and its preparation, and can solve the problems of slow recovery time, large side effects of hormone therapy, easy to leave sequelae and the like

Pending Publication Date: 2021-12-07
上海和义中药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hormone therapy has a lot of side effects; non-steroidal anti-inflammatory analgesics can only relieve pain, but cannot cure it; surgical therapy is traumatic, slow recovery time, and easily leaves sequelae, etc.;

Method used

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  • Compound traditional Chinese medicine for treating inflammatory pain and preparation method thereof
  • Compound traditional Chinese medicine for treating inflammatory pain and preparation method thereof
  • Compound traditional Chinese medicine for treating inflammatory pain and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0107] Experimental example 1: reduce rat whole blood viscosity

[0108] Get male Istar rats, body weight 250-310g, be divided into 5 groups at random, give capsules of the present invention of different doses and same volume normal saline respectively, once a day, continuously 5 days. 1.5 hours after the last administration, the patients were lightly anesthetized with ether, blood was collected from the abdominal aorta, and anticoagulated with heparin. Whole blood specific viscosity was measured with XN-5 blood viscometer. The results are shown in Table 1

[0109] Table 1 The effect of this capsule on the viscosity of whole blood in rats

[0110]

[0111] Note: Compared with the control group, *P<0.05, *P<0.01, **P<0.001 (the same below), the numbers in the table are all X±SD

[0112] The results show that this capsule can significantly reduce the specific viscosity of rat whole blood (low shear, high shear), and there is a significant difference with the control group,...

experiment example 2

[0113] Experimental example 2: inhibition of platelet aggregation

[0114] 1. Rabbit isolated platelet aggregation experiment

[0115] Rabbits with a body weight of about 2.2kg were taken, and the common carotid artery was catheterized for bloodletting in an awake state. 3.13% sodium citrate anticoagulant. The ratio of whole blood to anticoagulant is 9:1. Centrifuge at 1000rpm for 7 minutes to prepare PRP (platelet-rich plasma), absorb PRP and centrifuge at 3000rpm for 10 minutes to prepare PPP (platelet-poor plasma), and use SPA-III type according to the Born method PPP platelet aggregator for testing. Incubate capsules of the present invention with prepared PRP at 37°C for 10 minutes at different concentrations. The control group was given the same volume of normal saline. The final concentration of ADP is 1um. The experimental results are shown in Table 2;

[0116] Table 2 The effect of this capsule on the aggregation of isolated platelets in rabbits

[0117]

[0...

experiment example 4

[0138] Experimental example 4: anti-inflammatory effect (mouse ear swelling method)

[0139] Choose Kunming mice, body weight 20-25g, randomly group them according to body weight, and take different doses of drugs orally for three days. At the same time as the last administration, apply the inflammatory agent (containing 2% croton oil, 20% absolute ethanol, 5% distilled water and 73% ether) to the ears of the mice, and apply it to the front and back of the left ear, about 0.5 ml per mouse, The animals were sacrificed 2 hours after drug application, and the ear pieces of the same part of both ears were punched out with a 9 mm punch and weighed. The weight of the left ear piece minus the weight of the right ear piece was the degree of swelling, and the control group was statistically processed with the swelling degree of the drug administration. . The experimental results are shown in Table 7;

[0140] The results showed that oral administration of 10 and 20g / Kg cinnamon twig ...

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Abstract

The invention relates to a pharmaceutical composition for treating pain caused by body inflammation caused by trauma or internal injury. The inflammation mainly relates to clinical symptoms such as scapulohumeral periarthritis, gonitis, tenosynovitis and hydrocele of tunica vaginalis. The pharmaceutical composition consists of rhizoma curcumae longae, rhizoma et radix notopterygii, ramulus mori, radix cynanchi paniculati, radix clematidis and rhizoma homalomenae. Capsules are prepared by the following steps: soaking of the rhizoma curcumae longae, the rhizoma et radix notopterygii, the ramulus mori, the radix cynanchi paniculati, the radix clematidis and the rhizoma homalomenae, distilling with water vapor, extracting with ethanol, concentrating, granulating, drying and the like. The pharmaceutical composition disclosed by the invention has the characteristics of definite curative effect, no toxic or side effect, controllable quality standard, easiness in absorption and the like.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating pain caused by inflammations such as periarthritis of the shoulder, knee arthritis, meningitis and hydrocele caused by trauma or internal injury and a preparation method thereof. More precisely, it relates to a pharmaceutical composition using Chinese herbal medicine as a raw material and its preparation technology. Background technique [0002] Turmeric is the dry rhizome of Curcuma longa L. It has the effects of promoting blood circulation and promoting qi, promoting menstrual flow and relieving pain. Cure mainly Qi stagnation and blood stasis pain syndrome, rheumatic arthralgia. [0003] Turmeric was first recorded in "Xinxiu Materia Medica" in Tang Dynasty. It tastes pungent, bitter, warm and non-toxic. The main confidant knot accumulates phlegm, the lower qi breaks the blood, removes wind-heat, subsides carbuncle, and its power is stronger than Yujin. "Shengji Zonglu", "Yang's ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/48A61K47/69A61P3/06A61P9/00A61P25/28A61P29/00
CPCA61K36/9066A61K36/27A61K36/888A61K36/716A61K36/237A61K36/605A61K9/16A61K47/6951A61P29/00A61P9/00A61P3/06A61P25/28A61K2300/00
Inventor 刘海港宁美红兰江安
Owner 上海和义中药有限公司
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