Traditional Chinese medicine composition for treating or improving polycystic ovarian syndrome as well as preparation method and application thereof

A polycystic ovary and composition technology, applied in the field of traditional Chinese medicine preparations, can solve the problems of low adiponectin receptor level, poor insulin resistance, affecting ovarian function, etc. Effects of insulin resistance

Inactive Publication Date: 2021-12-10
天津中医药大学第一附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are currently no drugs or treatments that can fully cure or improve PCOS
[0004] PCOS is a major disease that affects women's reproductive health. In patients with PCOS, the intestinal SCFA levels represented by acetic acid and propionic acid are low, and the levels of serum TNF-α, IL-1β, IL-6 and other pro-inflammatory factors are high. Low levels of ...

Method used

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  • Traditional Chinese medicine composition for treating or improving polycystic ovarian syndrome as well as preparation method and application thereof
  • Traditional Chinese medicine composition for treating or improving polycystic ovarian syndrome as well as preparation method and application thereof
  • Traditional Chinese medicine composition for treating or improving polycystic ovarian syndrome as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Effect of Hashi Bushen Huatan Recipe on Metabolites of Gut Microbiota in Obese PCOS Rats and Mechanism of Improving Insulin Resistance

[0063] 1. Experimental materials

[0064] ① Experimental animals and grouping

[0065] 30 4-week-old specific pathogen-free (hereinafter referred to as "SPF class") (hereinafter referred to as "SPF class") female SD rats, weighing 90-110 g, provided by Beijing Huafukang Biotechnology Co., Ltd., certificate number : 110322200101143126. After one week of adaptive feeding with common food, the rats were randomly divided into blank group, model group, low-dose Chinese medicine group, medium-dose Chinese medicine group and high-dose Chinese medicine group, with 6 rats in each group.

[0066] ② drugs

[0067] The dosage of the medicinal ingredients of the traditional Chinese medicine composition: Cuscuta 20g, Ziheche 6g, Poria cocos 15g, Pueraria 15g, heather leaf 15g, Salvia miltiorrhiza 30g, bran fried herb atractylodes 10g, Morinda off...

Embodiment 2

[0153] Effect of Hashi Bushen Huatan Recipe on Ovarian Local Oxidative Stress in High-fat Diet-Induced Phlegm-damp Type PCOS Rats

[0154] 1. Experimental materials

[0155] ①Experimental animals

[0156] Thirty SPF-grade healthy female SD rats, 4 weeks old, with a body weight of (100±10) g, were purchased from Beijing Huafukang Biotechnology Co., Ltd., animal license number: 110322200101143126. The breeding temperature is 22-23°C, and the humidity is 50%-60%. Rat normal diet and high-fat diet were provided by Beijing Huafukang Biotechnology Co., Ltd.

[0157] ② Reagent

[0158] Letrozole (Beijing Suolaibao Technology Co., Ltd., article number: 15011956);

[0159] Sodium carboxymethylcellulose (Shanghai Yuanye Biotechnology Co., Ltd., article number: Y04M10X81657);

[0160] PBS (Beijing Suolaibao Technology Co., Ltd., article number: P1020-500);

[0161] Wright's staining solution (Beijing Suolaibao Technology Co., Ltd., item number: G1040);

[0162] Hematoxylin staining ...

Embodiment 3

[0241] Yang, female, 26 years old, married. Visit date: 2021-3-31.

[0242] Chief complaint: menopause for more than 2 months, 9 years after menstruation.

[0243] History of present illness: The patient usually has menstruation for 5-6 days / 1-3 months, with moderate amount, red color, occasional blood clots, dysmenorrhea (—). Lmp: 2021-1-30. Breast swelling before menstruation, backache during menstruation, emotional depression, Naco, sleep peacefully, two bowel movements. Pale tongue with white coating, slippery pulse.

[0244] Physical examination: height: 1.64m, weight 70Kg, BMI: 26.

[0245] Auxiliary examination: pelvic color Doppler ultrasound: no obvious abnormality was found.

[0246] Sex six items: T: 0.54, E2: 24.11, FSH: 3.95, LH: 7.37, PRL: 18.18, P<0.1.

[0247] TSH: 2.5480

[0248] Male triathlon: DHEA: 2.7, SHBG: 5.34, AND: 9.41.

[0249] Four blood lipid items: TG: 1.81, HDL-C: 1.03, LDL-C: 3.06, CHOL: 4.36.

[0250] INS: 18.0, FPG: 5.02, HOMA-IR: 4.0...

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Abstract

The invention provides a traditional Chinese medicine composition for treating or improving polycystic ovarian syndrome as well as a preparation method and application thereof The traditional Chinese medicine composition is prepared from the following raw materials of semen cuscutae, placenta hominis, poria cocos, radix puerariae, folium photiniae, radix salviae miltiorrhizae, rhizoma atractylodis fried with bran, prepared radix morindae officinalis, radix rehmanniae praeparata, roasted herba epimedii, spina gleditsiae, cornu cervi, radix gentianae, fried semen cassiae, cleaned fructus crataegi, rhizoma alismatis, folium nelumbinis and salted semen plantaginis. According to the traditional Chinese medicine composition as well as the preparation method and the application thereof provided by the invention, the reproductive disorder and metabolic disorder of the polycystic ovarian syndrome can be improved at the same time, and the SCFA level in intestinal tracts can be obviously improved; the levels of proinflammatory factors such as serum TNF-alpha, IL-1beta and IL-6 are reduced, so that the chronic hyporeactive inflammation is improved; the level of adiponectin receptors in fat, skeletal muscle and ovarian tissue is improved, and finally the insulin resistance of the polycystic ovarian syndrome is obviously improved; and the ovarian function of the polycystic ovarian syndrome and the maturation and development of follicles can be improved.

Description

technical field [0001] The disclosure relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine composition for treating or improving polycystic ovary syndrome, its preparation method and application. Background technique [0002] Polycystic ovary syndrome (PCOS), as a common reproductive endocrine disorder, affects about 6%-18% of women of reproductive age. PCOS not only affects the development of follicles, leading to menstrual disorders, amenorrhea, infertility and other reproductive disorders, but also interferes with the body's glucose and lipid metabolism pathways, and leads to type 2 diabetes, non-alcoholic fatty liver disease, metabolic syndrome and cardiovascular diseases. The occurrence of long-term complications brings huge mental and economic double pressure to patients. [0003] Since the etiology of PCOS is not yet fully understood, it brings certain difficulties in treatment. At present, the ...

Claims

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Application Information

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IPC IPC(8): A61K36/884A61P15/00A61P15/08A61K35/32A61K35/50
CPCA61K36/39A61K36/43A61K35/50A61K36/076A61K36/488A61K36/73A61K36/537A61K36/284A61K36/746A61K36/804A61K36/296A61K36/483A61K35/32A61K36/515A61K36/482A61K36/734A61K36/884A61K36/62A61K36/68A61K36/487A61K36/60A61K36/81A61K36/12A61K36/74A61K36/71A61K36/65A61K36/282A61P15/00A61P15/08A61K2236/331A61K2236/39A61K2300/00
Inventor 吴林玲闫颖张晗哈虹张吉金
Owner 天津中医药大学第一附属医院
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